加服抗痫煎剂治疗癫痫合并认知功能障碍的临床研究  

Clinical Study on the Addition of Anti-epileptic Decoction for the Treatment of Epilepsy Complicated with Cognitive Impairment

作　　者：张永全[1] 农朝雷[1] 陆婷钰 周明雪 胡芷颖 吴纪添 谭文澜[1] ZHANG Yong-quan;NONG Chao-lei;LU Ting-yu;ZHOU Ming-xue;HU Zhi-ying;WU Ji-tian;TAN Wen-lan(Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning,Guangxi,530011;Graduate School of Guangxi University of Chinese Medicine,Nanning,Guangxi,530200)

机构地区：[1]广西中医药大学附属瑞康医院,广西南宁530011 [2]广西中医药大学研究生院,广西南宁530200

出　　处：《广西中医药大学学报》2023年第3期10-13,共4页Journal of Guangxi University Of Chinese Medicine

基　　金：广西壮族自治区中医药管理局自筹经费科研课题项目(编号:GZZC2020073);广西中医药适宜技术开发与推广项目(编号:GZSY21-39);崇左市科技计划项目(编号:崇科FC2019009)。

摘　　要：[目的]观察抗痫煎剂治疗癫痫合并认知功能障碍患者的临床疗效。[方法]将93例癫痫合并认知功能障碍患者按数字表法进行随机分组,对照组46例,按发作类型予常规抗癫痫药物治疗,其中全面性发作癫痫患者予口服丙戊酸钠缓释片,药物分次口服,剂量按体重计算:20~30 mg/(kg·d);部分性发作癫痫患者予口服卡马西平片,剂量按体重计算:10~20 mg/(kg·d)。观察组47例,在对照组治疗基础上加服抗痫煎剂治疗,处方:石菖蒲10 g,半夏10 g,三七10 g(研末),天麻10 g,钩藤10 g(后下),地龙10 g。两组治疗2个月为1个疗程,连续治疗3个疗程。[结果]两组患者癫痫疗效比较,观察组总有效率为91.49%,对照组总有效率为76.09%,两组具有显著性差异(P<0.05)。两组患者脑电图改善情况比较,观察组总有效率为91.49%,对照组总有效率为73.91%,两组具有显著性差异(P<0.05)。观察组治疗后蒙特利尔认知评估量表评分高于治疗前(P<0.05),与对照组治疗后比较具有显著性差异(P<0.05)。[结论]加服抗痫煎剂治疗癫痫合并认知功能障碍具有良好疗效,无严重不良反应,可在临床进一步观察应用。[Objective]To observe the clinical curative effect of anti-epilepsy decoction in the treatment of epilep⁃sy patients with cognitive impairment.[Methods]93 cases patients with epilepsy complicated with cognitive impair⁃ment were randomly delivered into two groups according to the number table method,and 46 cases in the control group were treated with conventional antiepileptic drugs according to the type of seizures.Among them,patients with general⁃ized seizures took sodium valproate sustained-release tablets orally,and the drugs were divided into groups.Two drugs are taken orally at a time,and the dosage is calculated according to body weight:20~30 mg(/kg·d);patients with par⁃tial onset epilepsy are given oral carbamazepine tablets:10~20 mg(/kg·d).The other 47 cases in the observation group were treated with anti-epileptic decoction on the basis of the treatment in the control group.The prescription of anti-ep⁃ileptic decoction:Acorus calamus 10 g,Pinellia ternata 10 g,Panax notoginseng 10 g(powder),Gastrodia elata 10 g,Uncaria rhynchophylla 10 g(added later)and Earth worm 10 g.Two groups were treated for 2 months as a course of treatment,and 3 courses were continuously conducted.[Results]Comparing the treatment efficacy of epilepsy between the two groups,the total effective rate of the observation group was 91.49%,the total effective rate of the control group was 76.09%,and there was a significant difference between the two groups(P<0.05).After comparison of improvement in electroencephalogram between two groups of patients,the total effective rate of the observation group was 91.49%,the total effective rate of the control group was 73.91%,and there was a significant difference between the two groups(P<0.05).the montreal cognitive assessment after treatment in the observation group the scale score was higher than that before treatment(P<0.05),and compared with the control group after treatment,there was a significant difference(P<0.05).[Conclusion]The addition of anti-epilepsy decoction in the treatm

关 键 词：癫痫 认知障碍 抗痫煎剂 临床观察 

分 类 号：R277.7[医药卫生—中医学]