阿奇霉素联合美洛西林钠舒巴坦钠治疗肺炎支原体肺炎患儿的疗效观察  

Clinical observation of Azithromycin combined with Mezlocillin Sodium and Sulbactam Sodium in the Treatment of Children with Mycoplasma pneumoniae pneumonia

作　　者：张彦生 ZHANG Yansheng(Department of Neonatology,Kaifeng Maternal and Child Health Hospital,Kaifeng Henan 475003,China)

机构地区：[1]河南开封市妇幼保健院新生儿科,河南开封475003

出　　处：《临床研究》2023年第7期53-56,共4页Clinical Research

摘　　要：目的观察阿奇霉素联合美洛西林钠舒巴坦钠在肺炎支原体肺炎(MPP)患儿中的治疗效果。方法纳入2019年3月至2019年12月河南开封市妇幼保健院收治的118例MPP患儿开展研究,抽签分为观察组、对照组各59例,两组均予阿奇霉素治疗,观察组另加美洛西林钠舒巴坦钠治疗,两组患儿均连续治疗14 d。比较两组临床疗效、免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、C反应蛋白(CRP),肌酸激酶同工酶(CKMB)、临床指标(退热时间、喘息消失时间、止咳时间、啰音消失时间、胸部CT病灶消失时间及住院时间)及不良反应。结果观察组治疗有效率(94.92%)高于对照组(83.05%),差异有统计学意义(P<0.05)。治疗前,两组IgM、IgG、CRP、CKMB比较,差异无统计学意义(P>0.05);治疗后,观察组IgG高于对照组,IgM、CRP、CKMB低于对照组,差异有统计学意义(P<0.05)。观察组退热时间、喘息消失时间、止咳时间、啰音消失时间、胸部CT病灶消失时间及住院时间短于对照组,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论肺炎支原体肺炎患儿使用阿奇霉素联合美洛西林治疗有利于患儿病情恢复,可提高治疗效果,减轻机体炎症反应,缩短症状改善时间,安全性尚可,应用价值高。Objective To observe the therapeutic effect of azithromycin combined with mezlocillin sodium and sulbactam sodium in children with mycoplasma pneumoniae pneumonia(MPP).Methods A total of 118 MPP children admitted to Kaifeng Maternal and Child Health Hospital in Henan Province from March 2019 to December 2019 were included in the study.They were divided into observation group and control group by drawing lots with 59 cases each.Both groups were treated with azithromycin,and the observation group was additionally treated with mezlocillin sodium and sulbactam sodium.Both groups were treated for 14 days.The clinical efficacy,immunoglobulin M(IgM),immunoglobulin G(IgG),C-reactive protein(CRP),creatine kinase-MB(CKMB),clinical indicators(fever relief time,wheezing disappearance time,cough relief time,rale disappearance time,chest CT lesion disappearance time,and hospitalization time)and adverse reactions between two groups were compared.Results The effective rate of treatment in the observation group(94.92%)was higher than that in the control group(83.05%),with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in IgM,IgG,CRP,and CKMB between the two groups(P>0.05);After treatment,the IgG in the observation group was higher than that in the control group,while the IgM,CRP,and CKMB were lower than those in the control group,with a statistically significant difference(P<0.05).The observation group had shorter fever relieving time,wheezing disappearance time,cough relieving time,rale disappearance time,chest CT lesion disappearance time,and hospitalization time compared to the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion The treatment of azithromycin combined with mezlocillin in children with mycoplasma pneumoniae pneumonia is beneficial to the recovery of children's condition,can improve the treatment effect,reduce the inflammat

关 键 词：肺炎支原体肺炎 患儿 阿奇霉素 美洛西林钠舒巴坦钠 

分 类 号：R375.2[医药卫生—病原生物学]