4种中成药辅助治疗急性病毒性心肌炎的临床疗效及经济学评价  

Clinical Efficacy and economic Evaluation of four Kinds of traditional Chinese Patent Medicines in Adjuvant Treatment of acute Viral Myocarditis

作　　者：寇真真 KOU Zhenzhen(Traditional Chinese Medicine Pharmacy,Suixian Traditional Chinese Medicine Hospital,Shangqiu Henan 476900,China)

机构地区：[1]睢县中医院中药房,河南商丘476900

出　　处：《临床研究》2023年第7期110-114,共5页Clinical Research

摘　　要：目的探讨清开灵注射液、双黄连注射液、炎琥宁注射液、喜炎平注射液在辅助治疗急性病毒性心肌炎(VMC)中的临床疗效及经济学评价,为临床提供参考依据。方法研究对象选取为2018年7月至2020年12月睢县中医院收治的120例VMC患者,采用随机数字表法将患者分为A、B、C、D四组,每组30例,各组患者基础治疗方案相同,在此基础上A组患者静脉滴注清开灵注射液治疗,B组患者静脉滴注双黄连注射液治疗,C组患者静脉滴注炎琥宁注射液治疗,D组患者静脉滴注喜炎平注射液治疗,对比四组患者的疗效、心肌酶谱、心肌肌钙蛋白I(cTnⅠ)及不良反应发生率,并通过成本-效果、增量成本-效果比、敏感度进行经济学评价。结果A、B、C、D四组的治疗有效率分别为83.33%(25/30)、90.00%(27/30)、86.67%(26/30)、90.00%(27/30),各组疗效比较,差异无统计学意义(P>0.05)。治疗前后四组患者C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)炎性因子水平比较,差异无统计学意义(P>0.05);治疗后,各组患者CRP、IL-6、TNF-α均低于治疗前,差异有统计学意义(P<0.05)。治疗前后四组患者乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、羟丁酸脱氢酶(HBDH)及cTnⅠ水平比较,差异无统计学意义(P>0.05);治疗后,各组患者LDH、CK、CK-MB、HBDH及cTnⅠ水平低于治疗前,差异有统计学意义(P<0.05)。A、B、C、D四组的不良反应发生率分别为13.33%(4/30)、16.67%(5/30)、10.00%(3/30)、16.67%(5/30),各组不良反应发生率比较,差异无统计学意义(P>0.05)。C组成本-效果比低于其他各组,且与A组比较,B组每增加1%治疗有效率则节约4.13元,B组每增加1%治疗有效率节约22.72元,C组每增加1%治疗有效率需多花费6.73元。敏感性分析结果与成本-效果分析结果一致。结论4种中成药辅助治疗急性病毒性心肌炎均能获得良好的临床治疗效果,从经济学评价方面上�Objective To explore the clinical efficacy and economic evaluation of Qingkailing injection,Shuanghuanglian injection,Yanhuning injection and Xiyanping injection in the adjuvant treatment of acute viral myocarditis(VMC),so as to provide reference for clinical practice.Methods The study subjects were 120 VMC patients admitted to Suixian Traditional Chinese Medicine Hospital from July 2018 to December 2020.The patients were divided into four groups using a random number table method,A,B,C,and D,with 30 patients in each group.The basic treatment plan for each group was the same.On this basis,group A patients were treated with intravenous infusion of Qingkailing injection,group B patients with intravenous infusion of Shuanghuanglian injection,and group C patients with intravenous infusion of Yanhuning injection,group D patients were treated with intravenous infusion of Xiyanping injection,and the efficacy,myocardial enzyme spectrum,cardiac troponin I(cTnI),and incidence of adverse reactions were compared among the four groups.Economic evaluations were conducted through costeffectiveness,incremental cost-effectiveness ratio,and sensitivity.Results The effective rates of treatment in groups A,B,C,and D were 83.33%(25/30),90.00%(27/30),86.67%(26/30),and 90.00%(27/30),respectively.There was no statistically significant difference in the efficacy between the groups(P>0.05).The levels of C-reactive protein(CRP),Interleukin-6(IL-6)and tumor necrosis factors(TNF-α)in the four groups before and after treatment showed no significant difference(P>0.05),the levels of CRP,IL-6 and TNF-α in all groups were significantly lower than those before treatment(P<0.05).There was no statistically significant difference in the levels of lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),hydroxybutyrate dehydrogenase(HBDH),and cTnⅠ among the four groups of patients before and after treatment(P>0.05);After treatment,the levels of LDH,CK,CK-MB,HBDH,and cTnI in each group of patients were significantly lower tha

关 键 词：急性病毒性心肌炎 中成药 经济学评价 成本-效果 

分 类 号：R542.21[医药卫生—心血管疾病]