全反式维甲酸+三氧化二砷联合整体护理治疗急性早幼粒细胞性白血病的临床疗效观察  

Evaluation of the Effect of All-Trans Retinoic Acid Plus Arsenic Trioxide Combined Holistic Care in Primary Acute Promyelocytic Leukemia

作　　者：郭小朋 GUO Xiaopeng(Department of Hematology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang Henan 471300,China)

机构地区：[1]河南科技大学第一附属医院血液科,河南洛阳471300

出　　处：《临床研究》2023年第7期170-173,共4页Clinical Research

摘　　要：目的探讨全反式维甲酸+三氧化二砷联合整体护理干预治疗儿童急性早幼粒细胞性白血病的临床疗效。方法选取2019年10月至2021年10月河南科技大学第一附属医院收治的50例初治急性早幼粒细胞白血病患儿,根据随机数表法分为对照组(25例,行全反式维甲酸联合三氧化二砷的治疗并同时给予常规护理)和观察组(25例,在对照组基础上进行整体护理)。对比分析两组患者治疗后临床治疗效果、不良反应情况、护理满意度和生存率的差异。结果观察组完全缓解率(40.00%)高于对照组(20.00%);观察组复发率(56.00%)低于对照组(76.00%);观察组不良反应发生率(40.00%)低于对照组(64.00%);观察组护理满意度[(94.3±5.0)分]高于对照组[(87.6±4.8)分],差异有统计学意义(P<0.05)。两组患儿1年生存率差异无统计学意义(P>0.05),但观察组患儿的3年和5年生存率均明显高于对照组,差异有统计学意义(P<0.05)。结论全反式维甲酸+三氧化二砷联合整体护理干预不仅可降低急性早幼粒细胞白血病患儿的不良反应,还可延长其生存率,提高临床缓解率及护理满意度。Objective To study the clinical efficacy of all-trans retinoic acid plus arsenic trioxide combined holistic care in pediatric acute promyelocytic leukemia.Methods From October 2019 to October 2021,a total of 50 children with acute promyelocytic leukemia admitted to the First Affiliated Hospital of Henan University of Science and Technology were included,and according to random number table,they were divided into control group(25 cases,treated with all-trans retinoic acid combined with dioxium trioxide and given routine care at the same time)and observation group(25 cases,holistic care on the basis of control groups).The differences in clinical efficacy,adverse reactions,nursing satisfaction and survival rate after treatment were compared between the two groups.Results The complete remission rate of the children in the observation group was 40.00%,higher than that in the control group 20.00%,and the recurrence rate of the observation group was 56.00%,significantly lower than that in the control group 76.00%.The total incidence of adverse reactions in the observation group was 40.00%,which was significantly lower than 64.00%in the control group.The nursing satisfaction of the observation group[(94.3±5.0)]was higher than the control group[(87.6±4.8)],and the difference was statistically significant(P<0.05).There was no significant difference in 1-year survival between the two groups(P>0.05),but the 3-and 5-year survival rates of the observation group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion The all-trans retinoic acid plus arsenic trioxide combined holistic care can not only reduce the adverse effects in children with primary acute promyelocytic leukemia,but also prolong the survival rate and improve the clinical remission rate.

关 键 词：全反式维甲酸 三氧化二砷 急性早幼粒细胞性白血病 生存率 护理满意度 

分 类 号：R473[医药卫生—护理学]