新确证HIV阳性患者发生HCV感染的影响因素  

Influencing factors of HCV infection in newly confirmed HIV-positive patients

作　　者：王红[1] WANG Hong(Microbiological Laboratory of Jiamusi City Center for Disease Control and Prevention,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市疾病预防控制中心微生物检验科,黑龙江佳木斯154002

出　　处：《中国民康医学》2023年第10期18-20,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析新确证人类免疫缺陷病毒(HIV)阳性患者发生丙型肝炎病毒(HCV)感染的影响因素。方法:回顾性分析2018年1月至2021年12月该中心收治的414例新确证HIV阳性患者的临床资料。采集患者静脉血5 mL,先行HIV抗体确证实验(免疫印迹法),再行HCV-RNA检测,统计新确证HIV阳性患者HCV感染率及其影响因素。结果:414例新确证HIV阳性患者中,感染HCV29例,HCV感染率为7.00%(29/414);单因素分析结果显示,感染HCV与未感染HCV患者在性别、民族、婚姻状况和感染途径等方面比较,差异均无统计学意义(P>0.05);感染HCV与未感染HCV患者在年龄、受教育程度和吸毒史等方面比较,差异均有统计学意义(P<0.05);Logistic回归分析结果显示,41~59岁和吸毒均为影响新确证HIV阳性患者发生HCV感染的危险因素(OR>1,P<0.05),大专及以上受教育程度为新确证HIV阳性患者发生HCV感染的保护因素(OR<1,P<0.05)。结论:41~59岁和吸毒均为新确证HIV阳性患者发生HCV感染的危险因素,大专及以上受教育程度为新确证HIV阳性患者发生HCV感染的保护因素。Objective:To analyze influencing factors of hepatitis C virus(HCV)infection in newly confirmed human immunodeficiency virus(HIV)-positive patients.Methods:The clinical data of 414 newly confirmed HIV-positive patients in the center from January 2018 to December 2021 were retrospectively analyzed.5 mL of venous blood was collected from these patients,and HIV antibody confirmatory test(immunoblotting)was performed first.Then,HCV-RNA was detected.The HCV infection rate and its influencing factors in these newly confirmed HIV-positive patients were statistically analyzed.Results:Among the 414 newly confirmed HIV-positive patients,29 were infected with HCV,and the HCV infection rate was 7.00%(29/414).Univariate analysis showed that there were no significant differences in gender,ethnicity,marital status and route of infection among the patients with HCV infection and those without HCV infection(P>0.05).There were statistically significant differences in age,education level and drug abuse among the HCV-infected patients and the non-HCV-infected patients(P<0.05).Logistic regression analysis showed that the ages of 41-59 and drug abuse were risk factors for the HCV infection in the newly confirmed HIV-positive patients(OR>1,P<0.05),while education level at or above college level was a protective factor(OR<1,P<0.05).Conclusions:41-59 years old and drug abuse are the risk factors for the HCV infection in the newly confirmed HIV patients,while college education and above is the protective factor.

关 键 词：人类免疫缺陷病毒 丙型肝炎病毒 感染 吸毒 受教育程度 年龄 影响因素 

分 类 号：R512.91[医药卫生—内科学]