生长抑素联合奥美拉唑治疗急性胰腺炎患者的效果  

Effects of somatostatin combined with Omeprazole in treatment of patients with acute pancreatitis

作　　者：尚鸳鸳 SHANG Yuanyuan(Kaifeng Central Hospital,Kaifeng 475000 Henan,China)

机构地区：[1]开封市中心医院,河南开封475000

出　　处：《中国民康医学》2023年第10期51-53,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察生长抑素联合奥美拉唑治疗急性胰腺炎患者的效果。方法:选取2019年3月至2021年3月该院收治的120例急性胰腺炎患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各60例。两组均给予常规治疗,在此基础上,对照组予以静脉滴注奥美拉唑治疗,观察组在对照组基础上联合生长抑素静脉注射治疗,两组均治疗1周。比较两组临床疗效,治疗前后炎性因子[肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)]、胰腺体部血流指标(血流量、毛细血管表面通透性、血容量)、外周血白细胞计数、D-乳酸、二胺氧化酶(DAO)水平,以及尿乳果糖/甘露醇(L/M)值。结果:观察组治疗总有效率为93.33%,高于对照组的75.00%,差异有统计学意义(P<0.05);治疗1周后,两组血清TNF-α、IL-6、外周血白细胞、D-乳酸、DAO水平和L/M值、毛细血管表面通透性均低于治疗前,且观察组低于对照组;两组血流量、血容量均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:生长抑素联合奥美拉唑治疗急性胰腺炎患者可提高治疗总有效率,改善胰腺体部血流指标水平,降低炎性因子、外周血白细胞计数、D-乳酸、DAO水平和L/M值,优于单纯奥美拉唑治疗效果。Objective:To observe effects of somatostatin combined with Omeprazole in treatment of patients with acute pancreatitis.Methods:A prospective study was conducted on 120 patients with acute pancreatitis admitted to the hospital from March 2019 to March 2021.They were divided into control group and observation group according to the random number table method,60 cases in each.Both groups were given routine treatment.On this basis,the control group was given intravenous infusion of Omeprazole,while the observation group was treated with somatostatin intravenous injection on the basis of that of the control group.Both groups were treated for 1 week.The clinical efficacy,the inflammatory factor levels[tumor necrosis factor(TNF-α),interleukin-6(IL-6)],the pancreatic body blood flow index levels(blood flow,capillary surface permeability,blood volume),the peripheral white blood cells,D-lactic acid,diamine oxidase(DAO)levels and urinary lactulose/mannitol(L/M)values were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 93.33%,which was higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After 1 week of treatment,the levels of serum TNF-α,IL-6,peripheral white blood cells,D-lactic acid,DAO,L/M and capillary surface permeability in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the blood flow and the blood volume levels of the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Somatostatin combined with Omeprazole in the treatment of the patients with acute pancreatitis can improve the total effective rate of treatment,improve the blood flow index levels of pancreatic body,and reduce the inflammatory factor levels,the peripheral blood D-lactic acid and D

关 键 词：急性胰腺炎 生长抑素 炎性因子 肠道黏膜屏障功能 胰腺血流 

分 类 号：R657.5[医药卫生—外科学]