百里醌的生物活性及防治新型冠状病毒感染机制的最新进展  

Research progress of thymoquinone on its bioactivity and mechanism in preventing SARS-CoV-2 infection

作　　者：柳舟[1] 张亮[2] 董卫国[3] 詹丽英[1] 张吉翔[3] 曹明为 王晶 LIU Zhou;ZHANG Liang;DONG Weiguo;ZHAN Liying;ZHANG Jixiang;CAO Mingwei;WANG Jing(Dept.of Intensive Care Unit,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Dept.of Radiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Dept.of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Dept.of PediatricⅠ,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Dept.of Intensive Care Unit,Baokang County People's Hospital,Xiangyang 441600,Hubei,China)

机构地区：[1]武汉大学人民医院重症医学科,湖北武汉430060 [2]武汉大学人民医院放射科,湖北武汉430060 [3]武汉大学人民医院消化内科,湖北武汉430060 [4]武汉大学人民医院儿科Ⅰ科,湖北武汉430060 [5]保康县人民医院重症医学科,湖北襄阳441600

出　　处：《武汉大学学报（医学版）》2023年第6期660-666,共7页Medical Journal of Wuhan University

摘　　要：百里醌是毛莨科植物黑种草籽中提取的天然单体,低毒高效,具有抗肿瘤、抗炎、抗氧化应激、抗纤维化、保护缺血再灌注损伤、抗病毒、镇痛、抗焦虑/惊厥、抗辐射等生物活性。百里醌临床上广泛运用于多种疾病,如恶性肿瘤、骨关节炎、心血管疾病、糖尿病、帕金森、类风湿、哮喘、炎症性疾病、皮肤病、消化系统疾病等。最新研究表明百里醌不仅具有广谱抗病毒效应,同时可一定程度上阻断新型冠状病毒(SARS-CoV-2)进入宿主细胞,减少病毒复制,减轻靶器官损伤,发挥防治功效。本文综合百里醌国内外最新研究进展,对其生物活性及防治SARS-CoV-2感染的相关机制进行总结及展望。Thymoquinone(TQ)is a natural monomer extracted from Nigella sativa,characterized by high efficiency with low toxicity and diversified bioactivities such as anti-tumor,anti-inflammatory,antioxidant,anti-fibrosis,protecting against ischemia-reperfusion injury,anti-virus,analgesia,anti-anxiety,anti-convulsion,and even anti-radiation.TQ can be used for a variety of clinical diseases,including malignant tumors,osteoarthritis,cardiovascular and cardiovascular disease,diabetes,Parkinson's disease,rheumatoid disease,asthma,inflammatory disease,skin disease,digestive system disease,etc.Recent studies also suggested that TQ has a broad-spectrum of anti-viral effect and could block SARS-CoV-2 from invading host cells,reducing virus replication,and avoiding series of target organ damage,so it was embodied therapeutic and preventive effects.In conclusion,the latest researches of TQ in Chinese and Englishi were reviewed,both biological activity and related mechanism of SARS-CoV-2 prevention have been summarized and prospected.

关 键 词：百里醌 肿瘤 炎症 氧化应激 缺血再灌注 纤维化 新型冠状病毒 

分 类 号：R932[医药卫生—生药学]