硫化铋基纳米材料在癌症诊断和治疗中的应用  

Application of bismuth sulfide based nanomaterials in cancer diagnosis and treatment

作　　者：杨钟炜 王龙伟 张健 于欣 刘晶 Zhongwei Yang;Longwei Wang;Jian Zhang;Xin Yu;Jing Liu(Institute for Advanced Interdisciplinary Research,University of Jinan,Jinan 250022,China;Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education School of Medicine,Northwest University,Xi’an 710069,China;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing 100190,China;Department of Life Sciences,Chalmers University of Technology,Göteborg 41296,Sweden)

机构地区：[1]济南大学前沿交叉科学研究院,济南250022 [2]西北大学生命科学学院,西安710069 [3]国家纳米科学中心,中国科学院纳米生物效应与安全性重点实验室,北京100190 [4]Department of Life Sciences,Chalmers University of Technology,Kemivägen 41296,Sweden

出　　处：《科学通报》2023年第16期2101-2115,共15页Chinese Science Bulletin

基　　金：国家自然科学基金(52272212);山东省杰出青年基金(ZR2022JQ20);山东省泰山学者青年专家项目(tsqn202211168)资助。

摘　　要：癌症仍然是目前威胁人类生命和健康的主要疾病.随着纳米技术的发展,集成不同诊断和治疗功能的多功能纳米材料已成为纳米研究中最活跃的领域.其中,Bi_(2)S_(3)基纳米材料由于其特殊的物理化学特性及生物相容性等,在生物医学领域引起了极大的关注.本文系统地总结了Bi_(2)S_(3)基纳米材料的形貌调控及缺陷调控策略,概述了Bi_(2)S_(3)基纳米材料最近在癌症诊断和治疗方面的研究进展.此外,强调和讨论了Bi_(2)S_(3)基纳米材料的生物安全性和生物分布,并对进一步增强Bi_(2)S_(3)基纳米材料生物相容性的方式进行了概括.最后,为设计下一代Bi_(2)S_(3)基纳米材料作为抗肿瘤药物提供了新的见解.Cancer is a complicated disease with a significant degree of heterogeneity,despite having made impressive advances in the field of cancer treatment,cancer remains a major threat to human life and health.The complexity of cancer on the genetic and phenotypic planes defines its clinical diversity and the difficulty of treatment.The increasing incidence of integrative types as well as individual types of cancer with the passage of time has prompted the development of novel cancer treatment strategies.Current treatment protocols are based on correcting gene mis-expression,blocking nutrient delivery to the tumor,or destroying the cancer cells.Often,surgery cannot completely eliminate all cancer cells in the body,leaving the cancer at risk of recurrence and high mortality.Chemotherapy and radiotherapy have serious side effects on normal tissue cells in the body while killing cancer cells,and these approaches are still unsatisfactory due to insufficient specificity and dose limitations.The development of novel drugs with specific targeted therapies or site-specific delivery systems to deliver therapeutic agents can greatly avoid the toxicity to healthy tissues caused by non-specificity.The preparation of nanomaterials is the most important basic technology in nanotechnology research,as well as a prerequisite for nanoapplication technology and nano-industrialization,which has been the key focus of nanotechnology researchers’attention and research.With the development of nanotechnology,multifunctional nanomaterials,which integrate various diagnostic and therapeutic functions,have become the most active field in nanoscale research,and have been applied in the fields of early screening of tumors,identification of tumor biomarkers,targeted release of chemotherapeutic drugs and development of novel therapies.After decades of development,biomedical nanomaterials have been applied to cancer diagnosis,tumor imaging,drug loading,tumor therapy,etc.They have excellent biocompatibility and biodistribution,with advantages unmatched

关 键 词：Bi_(2)S_(3) 制备 成像 诊断 治疗 多功能化 

分 类 号：R318.08[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]