针刺作用于间充质干细胞治疗缺血性卒中的科学依据探讨  

Scientific basis of acupuncture on mesenchymal stem cells for treating ischemic stroke

作　　者：巴特 孙楷航 王婧 王泽然 桑博默 李泓宽 郭昊然 杨雪 郑玉洁 赵晓峰[1,2] BA Te;SUN Kai-hang;WANG Jing;WANG Ze-ran;SANG Bo-mo;LI Hong-kuan;GUO Hao-ran;YANG Xue;ZHENG Yu-jie;ZHAO Xiao-feng(Department of Special Needs of Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193)

机构地区：[1]天津中医药大学第一附属医院针灸特需科,天津300193 [2]国家中医针灸临床医学研究中心,天津300193

出　　处：《中国针灸》2023年第6期691-696,共6页Chinese Acupuncture & Moxibustion

基　　金：国家重点研发计划项目:2018YFC1706001;天津中医药大学研究生科研创新项目:YJSKC-20202002。

摘　　要：探讨针刺作用于间充质干细胞治疗缺血性卒中的科学依据。间充质干细胞移植治疗缺血性卒中早期炎性级联反应引起的组织损伤具有极大潜力,但实际转化却受到诸多因素限制,如何提高间充质干细胞的归巢效率是增强其疗效的首要问题。通过梳理文献总结针刺与间充质干细胞移植疗法抑制缺血性卒中引起的炎性级联反应的可能机制,并提出假说:针刺可促进缺血灶分泌基质细胞衍生因子-1α(SDF-1α)调控SDF-1α/CXC趋化因子受体4(CXCR4)轴,从而提高间充质干细胞移植的归巢效率,发挥其神经保护功能,提高临床转化能力。The scientific basis of acupuncture on mesenchymal stem cells(MSCs)for treating ischemic stroke(IS)is discussed.MSCs transplantation has great potential for the treatment of tissue damage caused by early stage inflammatory cascade reactions of IS,but its actual transformation is limited by various factors.How to improve the homing efficiency of MSCs is the primary issue to enhance its efficacy.As such,the possible mechanisms of acupuncture and MSCs transplantation in inhibiting inflammatory cascade reactions induced by IS are explored by reviewing literature,and a hypothesis that acupuncture could promote the secretion of stromal cell-derived factor-lα(SDF-1a)from ischemic foci to regulate SDF-1a/CXC chemokine receptor 4(CXCR4)axis,thereby improving the homing efficiency of MSCs transplantation,exerting its neuroprotective function,and improving the bed transformation ability,is proposed.

关 键 词：缺血性卒中 针刺 间充质干细胞 基质细胞衍生因子-1α(SDF-1α)/CXC趋化因子受体4(CXCR4)轴 

分 类 号：R245[医药卫生—针灸推拿学]