导电水凝胶及其在糖尿病创面修复中的应用研究进展  

Research advances on conductive hydrogels and their applications in the repair of diabetic wounds

作　　者：吕洋 褚万立[2] 陈煜[1] 李玉婧 马西兰[1] Lyu Yang;Chu Wanli;Chen Yu;Li Yujing;Ma Xilan(School of Materials Science and Engineering,Beijing Institute of Technology,Beijing 100081,China;Department of Burns and Plastic Surgery,the Fourth Medical Center of PLA General Hospital,Beijing 100048,China;School of Medical Technology,Beijing Institute of Technology,Beijing 100081,China)

机构地区：[1]北京理工大学材料学院,北京100081 [2]解放军总医院第四医学中心烧伤整形医学部,北京100048 [3]北京理工大学医学技术学院,北京100081

出　　处：《中华烧伤与创面修复杂志》2023年第6期586-590,共5页Chinese Journal of Burns And Wounds

基　　金：北京理工大学青年教师学术启动计划(3320011182201);北京市自然科学基金-海淀原始创新联合基金(L222036);基础加强计划项目(2022-JCJQ-ZD-224-12)。

摘　　要：导电水凝胶作为一种新型功能性创面敷料,因具有适宜的电导率、良好的保湿性、优异的生物相容性,以及介导细胞迁移和增殖、促进血管生成和胶原沉积等生物学作用,在创面修复领域具有广阔的应用前景。通过结合临床上的电刺激疗法,导电水凝胶初步体现出促进肉芽组织形成、再上皮化和创面愈合的疗效,为糖尿病创面修复提供了新的治疗思路。该文基于不同的导电机制,总结了近年来电子导电型水凝胶和离子导电型水凝胶的研究进展,同时特别介绍了导电水凝胶在糖尿病创面修复中的应用情况,并对未来导电水凝胶创面敷料的发展进行展望。As a new type of functional wound dressing,conductive hydrogel,shows broad prospects of application in the field of wound repair due to its suitable electrical conductivity,good moisture retention,excellent biocompatibility,and biological effects such as mediating cell migration and proliferation,and promoting angiogenesis and collagen deposition.Combined with the clinical electrical stimulation therapy,the conductive hydrogel primarily showed curative effects of promoting granulation tissue formation,re-epithelialization,and wound healing,providing a new treatment idea for the repair of diabetic wounds.This review summarized the research advances of electronic conductive hydrogels and ionic conductive hydrogels in recent years based on different conductive mechanisms.Meanwhile,the applications of conductive hydrogel in the diabetic wound repair were specifically introduced,and the future development of conductive hydrogel wound dressing was prospected.

关 键 词：糖尿病 水凝胶 敷料 水胶体 创面修复 电子导电型水凝胶 离子导电型水凝胶 

分 类 号：R587.2[医药卫生—内分泌] R318.08[医药卫生—内科学]