基于铁死亡机制的多模式联合治疗肿瘤的纳米递药系统的研究进展  

Research progress in nano drug delivery system for multimodal therapy for tumor based on ferroptosis mechanism

作　　者：阚玉萍 李士壮 王雪莹[2] 苏慧[1] 阎雪莹[1] KAN Yu-ping;LI Shi-zhuang;WANG Xue-ying;SU Hui;YAN Xue-ying(Heilongjiang University of Traditional Chinese Medicine,Harbin 150000;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150000)

机构地区：[1]黑龙江中医药大学,哈尔滨150000 [2]黑龙江中医药大学附属第一医院,哈尔滨150000

出　　处：《中南药学》2023年第6期1521-1528,共8页Central South Pharmacy

基　　金：黑龙江省自然科学基金项目(No.LH2020H096);黑龙江省自然科学基金项目(No.LH2021H102);黑龙江中医药管理局资助项目(No.ZHY2020-112)。

摘　　要：铁死亡是一种新型的铁依赖性非凋亡性细胞死亡,其显著特点是细胞内脂质活性氧生成与降解平衡失调。研究表明,大部分的肿瘤病变与铁死亡有着密切的关联,铁死亡是调节肿瘤治疗的重要枢纽。由于肿瘤异质性和某些特定条件的限制,单一的诱导铁死亡策略以及化学疗法并不能得到预期的治疗效果。最近的几项研究将铁死亡与多种治疗模式联合应用取得了突破性的进展,先进的纳米技术为铁供应和药物传递开辟了新的途径,尤其是在控制药物的稳定性、生物分布、细胞靶向性和药物释放动力学等方面取得了很大进展。本文对基于铁死亡机制联合化疗、光学疗法、免疫疗法等多模式治疗肿瘤的纳米递药技术最新研究进展进行了综述。Ferroptosis is a new type of iron-dependent non-apoptotic cell death,characterized by the imbalance of intracellular lipid reactive oxygen species production and degradation.Studies have shown that most tumor lesions are closely related to ferroptosis,which is an important hub for regulating cancer treatment.Due to the limitation of tumor heterogeneity and certain specific conditions,ferroptosis alone and chemotherapy fail to obtain the desired therapeutic effect.Recent studies have made breakthroughs in the combined application of ferroptosis and multiple treatment modalities.Moreover,advanced nanotechnology has opened up new avenues for iron supply and drug delivery,especially in controlling drug stability,biodistribution,cell targeting,and drug release kinetics.This paper reviewed the latest research progress in nano-drug delivery based on ferroptosis mechanism combined with chemotherapy,optical therapy,immunotherapy and other multimodal therapy for tumor.

关 键 词：铁死亡 肿瘤 纳米技术 多模式联合治疗 

分 类 号：R943[医药卫生—药剂学]