铁死亡的分子调控机制及其在急慢性肝病中的进展  

Molecular mechanism of ferroptosis and its advances in acute and chronic liver diseases

作　　者：刘淼 沈佳妍 李盼盼 张凯悦 张议文 王涛[1] 刘梦扬 LIU Miao;SHEN Jia-yan;LI Pan-pan;ZHANG Kai-yue;ZHANG Yi-wen;WANG Tao;LIU Mengyang(Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617)

机构地区：[1]天津中医药大学中医药研究院,天津301617

出　　处：《中南药学》2023年第6期1572-1580,共9页Central South Pharmacy

基　　金：国家自然科学基金项目(No.82004062)。

摘　　要：铁死亡是一种铁依赖性非凋亡的细胞死亡形式。铁代谢紊乱、氧化系统失衡和不饱和脂肪酸脂质过氧化积累是铁死亡的主要特征。铁死亡涉及多种疾病的生理及病理过程。近年来,由于肝脏易发生氧化损伤且其是体内调节铁稳态的主要器官,铁死亡在急慢性肝病的研究领域中迅速受到关注。本文对铁死亡的分子调控机制及其在急慢性肝病中的研究进展进行综述,以期为靶向铁死亡治疗急慢性肝病提供新的思路及研究方向。Ferroptosis is an iron dependent and non-apoptotic form of cell death.Iron metabolism disorder,oxidation system imbalance and accumulation of unsaturated fatty acid lipid peroxidation are the main characteristics of ferroptosis.Ferroptosis is involved in the physiological and pathological processes of many diseases.In recent years,so as the liver is prone to oxidative damage and is the main organ regulating iron homeostasis in the body,ferroptosis has attracted rapid attention in treating acute and chronic liver diseases.This paper reviewed the molecular regulation mechanism of ferroptosis and its research progress in acute and chronic liver diseases aiming to providing new research directions for the treatment of acute and chronic liver diseases by targeting ferroptosis.

关 键 词：铁死亡 急慢性肝病 分子机制 

分 类 号：R96[医药卫生—药理学] R575[医药卫生—药学]