氧化应激诱导高血压的分子遗传学机制研究进展  

Research progress in molecular genetic mechanism of oxidative stress-induced hypertension

作　　者：张慧丹 孟璐 龙涛 丁启龙[1] ZHANG Hui-dan;MENG Lu;LONG Tao;DING Qi-long(Teaching Center for Pharmaceutical Experiments,China Pharmaceutical University,Nanjing 211198)

机构地区：[1]中国药科大学药学实验教学中心,南京211198

出　　处：《中南药学》2023年第6期1599-1604,共6页Central South Pharmacy

基　　金：国家自然科学基金项目(No.81872930)。

摘　　要：高血压病由许多单核苷酸多态性相互作用引起,由单一罕见基因突变引起的与高血压相关的综合征也逐渐被发现。氧化应激是高血压发生的主要原因之一,通过影响肾素-血管紧张素系统、内皮系统和氧化应激系统相关基因的多态性,增加人类对高血压病的易感性。本文旨在从分子遗传学角度阐述氧化应激如何增加高血压病易感性并诱导高血压的发生,为高血压发病机制的深入探索以及高血压的预防和治疗提供参考,为抗氧化剂的发展提供更广阔的空间。Hypertension is caused by the interaction of many single nucleotide polymorphisms(SNPs),and the syndrome related to hypertension caused by a single rare gene mutation is also gradually discovered.Oxidative stress is a main cause of hypertension and increases the susceptibility of humans to hypertension by affecting the gene polymorphisms related to the renin angiotensin system,endothelial system,and oxidative stress system.This article illustrates how oxidative stress increases the susceptibility of hypertension and eventually induces the occurrence of hypertension from the genetic molecular biology perspective.This article also provides a reference for in-depth explanation of pathogenesis of hypertension and possible resolutions for hypertension prevention and treatment,and advocates a more extensive use of antioxidants.

关 键 词：高血压 遗传 易感性 基因多态性 候选基因 氧化应激 

分 类 号：R544.1[医药卫生—心血管疾病]