肿瘤微环境调节肿瘤细胞耐药性的研究现状  

Research status of related to tumor microenvironment regulating drug resistance

作　　者：穆玉慧 王志鹏 崔莉莉 王彬 蒙博素 高守红 MU Yu-hui;WANG Zhi-peng;CUI Li-li;WANG Bin;MENG Bo-su;GAO Shou-hong(College of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,Yunnan Province,China;Department of Pharmacy,Second Affiliated Hospital of The Naval Medical University,Shanghai 200003,China;Chemical and Biological Engineering,Yichun University,Yichun 336000,Jiangxi Province,China)

机构地区：[1]云南中医药大学中药学院,云南昆明650500 [2]海军军医大学第二附属医院药剂科,上海200003 [3]宜春学院化学与生物工程学院,江西宜春336000

出　　处：《中国临床药理学杂志》2023年第11期1652-1656,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82204819);上海市卫生健康委员会青年基金资助项目(20214Y0319);上海长征医院“金字塔人才工程”优秀青年医师基金资助项目(YQ672)。

摘　　要：肿瘤细胞与肿瘤微环境相互作用是产生多药耐药的重要原因之一。基质微环境(TME)的组分复杂,主要包括肿瘤成纤维细胞、脂肪细胞、免疫细胞等,这些成分均可促进肿瘤耐药性的获得。肿瘤相关成纤维细胞可以分泌多种因子,调节或反向调节肿瘤耐药;脂肪细胞分泌的细胞因子或高能代谢物,可促进肿瘤耐药;肿瘤相关巨噬细胞是TME中最重要的免疫细胞,其分型对肿瘤内免疫微环境密切相关,也可调节肿瘤耐药。因此,靶向TME中不同基质细胞群对降低肿瘤耐药性十分重要。本文详细地阐述了TME中不同组分促进肿瘤耐药的作用机制及靶向TME的研究现状,以期为肿瘤的治疗提供参考。The interaction between tumor cells and the tumor microenvironment(TME)is one of the important mechanisms for the development of drug resistance.TME has complex components,mainly including tumor fibroblasts,adipocytes,and immune cells,all of which can promote the acquisition of drug resistance.Tumor-associated fibroblasts can secrete a variety of factors that regulate or inversely regulate drug resistance;adipocytes secrete cytokines or high-energy metabolites that promote drug resistance;tumor-associated macrophages are the most important immune cells in the TME,and their classification is closely related to the immune microenvironment within the tumor,which can also regulate drug resistance.Therefore,targeting different stromal cell populations in TME is important to reduce drug resistance.In this paper,the mechanisms of action of different elements in TME to promote drug resistance and the research progress of targeting TME are summarized in detail,providing a reference for tumor treatment.

关 键 词：肿瘤微环境 耐药 肿瘤相关成纤维细胞 肿瘤相关巨噬细胞 肿瘤相关脂肪细胞 

分 类 号：R979[医药卫生—药品]