46例艾滋病合并重度贫血的临床特征及病因分析  

Clinical characteristics and etiology analysis of 46 cases of acquired immuno-deficiency syndrome with severe anemia

作　　者：陈莉[1] CHEN Li(Department of Infection,Third People's Hospital of Shenzhen,Shenzhen 518000,China)

机构地区：[1]深圳市第三人民医院感染科,518000

出　　处：《中国现代药物应用》2023年第11期59-61,共3页Chinese Journal of Modern Drug Application

基　　金：2020年国家自然科学基金委员会资助面上项目(项目编号:81971915)项目名称:男男同性性行为HIV-1CRF01-AE感染者疾病进展、ART治疗效果与肠道菌群的相互作用研究。

摘　　要：目的 分析艾滋病合并重度贫血患者的临床特征和病因。方法 回顾性分析46例艾滋病合并重度贫血患者的临床资料,了解重度贫血发生的临床特征及病因,分析其与年龄、高效抗逆转录病毒疗法(HAART)治疗、CD4 T淋巴细胞计数、艾滋病病毒核糖核酸(HIV-RNA)、药物、感染、肿瘤之间的关系。结果 46例艾滋病合并重度贫血患者中已HAART治疗患者14例,10例使用含有齐多夫定片的HAART方案,3例发生恶性肿瘤,未行HAART治疗或治疗后自行停药的32例患者中88%患者CD4 T淋巴细胞计数<50个/μl,HIV-RNA>10~6 IU/ml患者占53%,与多重机会性感染有关,且为严重感染。13例患者死亡、占28%。结论 艾滋病合并重度贫血主要与CD4 T淋巴细胞计数、HIV-RNA、HAART药物、恶性肿瘤、机会性感染等主要因素相关。Objective To analyze the clinical characteristics and etiology of acquired immunodeficiency syndrome with severe anemia.Methods The clinical data of 46 cases of acquired immuno-deficiency syndrome with severe anemia were retrospectively analyzed to understand the clinical characteristics and etiology of the occurrence of severe anemia,and to analyze the correlation between severe anemia and age,highly active antiretroviral therapy(HAART),CD4 T lymphocyte count,human immunodeficiency virus ribonucleic acid(HIV-RNA),drugs,infection,and tumor.Results Among 46 cases of acquired immuno-deficiency syndrome with severe anemia,14 patients had received HAART therapy,10 of whom were on HAART regimens containing zidovudine tablets,and 3 cases developed malignancy;of the 32 patients who did not undergo HAART therapy or discontinued the drug on their own after treatment,88%had CD4 T-lymphocyte counts<50/μl and 53%had HIV-RNA>106 IU/ml,which was associated with multiple opportunistic infections and were severely infected.13 patients died,accounting for 28%.Conclusion Acquired immuno-deficiency syndrome with severe anemia is mainly correlated to CD4 T lymphocyte count,HIV-RNA,HAART drugs,malignancy,opportunistic infection and other main factors.

关 键 词：艾滋病 重度贫血 高效抗逆转录病毒疗法治疗 CD4 T淋巴计数 

分 类 号：R512.91[医药卫生—内科学] R556[医药卫生—临床医学]