老年心绞痛合并高脂血症采取阿托伐他汀钙大剂量用药与小剂量用药的效果对比  

Comparison on the effect of high dose and low dose of atorvastatin calcium in elderly angina pectoris complicated with hyperlipidemia

作　　者：杨璐 YANG Lu(Shenyang Ninth People's Hospital,Shenyang 110024,China)

机构地区：[1]沈阳市第九人民医院,110024

出　　处：《中国现代药物应用》2023年第11期72-74,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨不同剂量阿托伐他汀钙在老年心绞痛合并高脂血症中的临床疗效。方法 180例老年心绞痛合并高脂血症患者,采用随机数字表法分为对照组及观察组,每组90例。对照组患者给予小剂量阿托伐他汀钙,观察组患者给予大剂量阿托伐他汀钙。对比两组患者临床治疗效果及治疗前后炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、血脂指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)]水平。结果 观察组患者治疗总有效率97.78%(88/90)明显高于对照组的88.89%(80/90),差异有统计学意义(P<0.05)。治疗后,观察组患者hs-CRP水平为(5.14±2.13)mg/L、TNF-α水平为(79.35±3.57)pg/L、IL-6水平为(7.35±2.16)μg/L,明显低于对照组的(8.32±2.14)mg/L、(96.54±3.24)pg/L、(10.25±2.47)μg/L,差异有统计学意义(P<0.05)。治疗后,观察组TC(3.21±1.18)mmol/L、TG(1.93±0.21)mmol/L、LDL-C(2.05±0.14)mmol/L低于对照组的(4.35±1.21)、(2.36±0.42)、(2.85±0.32)mmol/L,HDL-C(1.89±0.11)mmol/L高于对照组的(1.43±0.17)mmol/L,差异有统计学意义(P<0.05)。结论 大剂量阿托伐他汀钙可改善老年心绞痛合并高脂血症患者炎症反应和血脂水平,治疗效果显著。Objective To discuss the clinical efficacy of high dose and low dose of atorvastatin calcium in elderly angina pectoris complicated with hyperlipidemia.Methods A total of 180 elderly patients with angina pectoris and hyperlipidemia were divided into control group and observation group according to the random numerical table,with 90 cases in each group.The control group was given a low dose of atorvastatin calcium,and the observation group was given a high dose of atorvastatin calcium.Both groups were compared in terms of clinical therapeutic effect,inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],blood lipid indexes[low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG),total cholesterol(TC)]level before and after treatment.Results The total effective rate of 97.78%(88/90)in the observation group was higher than that of 88.89%(80/90)in the control group,and the difference was statistically significant(P<0.05).After treatment,the observation group had hs-CRP level of(5.14±2.13)mg/L,TNF-αlevel of(79.35±3.57)pg/L,and IL-6 level of(7.35±2.16)μg/L,which were significantly lower than those of(8.32±2.14)mg/L,(96.54±3.24)pg/L,and(10.25±2.47)μg/L in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of TC,TG and LDL-C in the observation group were(3.21±1.18),(1.93±0.21)and(2.05±0.14)mmol/L,which were lower than those of(4.35±1.21),(2.36±0.42)and(2.85±0.32)mmol/L in the control group;HDL-C of(1.89±0.11)mmol/L in the observation group was higher than that of(1.43±0.17)mmol/L in the control group;the differences were statistically significant(P<0.05).Conclusion High dose of atorvastatin calcium has significant effect on elderly patients with angina pectoris and hyperlipidemia,and can improve the inflammatory response and blood lipid level of patients.

关 键 词：心绞痛 高脂血症 阿托伐他汀钙 大剂量 小剂量 老年 

分 类 号：R541.4[医药卫生—心血管疾病] R589.2[医药卫生—内科学]