Association between serum albumin levels and disease severity in adult patients with dengue: A 7-year retrospective cohort study in China's Mainland  

作　　者：Changtai Wang Huiqin Yang Jielan Xu Jian Wang Lingzhai Zhao Wenxin Hong Fuchun Zhang 

机构地区：[1]Department of Infectious Disease,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou,China [2]Department of Clinical Laboratory,Guangzhou Eighth People's Hospital,Guangzhou Medical University,Guangzhou,China [3]Department of Infectious Disease,Guangzhou Red Cross Hospital,Jinan University,Guangzhou,China

出　　处：《Asian Pacific Journal of Tropical Medicine》2023年第5期204-212,I0001,共10页亚太热带医药杂志（英文版）

基　　金：supported by Special Program of Science and Technology of Guangdong Province(Grant No.:2013A020229001);the Major Program of Guangzhou Healthcare Collaborative Innovation(Grant No.:201803040006);Basic and applied basic research project jointly funded by the University of Guangzhou(Grant No.:2023A03J0810).

摘　　要：Objective:To identify the association between serum albumin levels and disease severity among adult patients with dengue in China's Mainland.Methods:This retrospective cohort study analyzed the data of adult patients(aged≥18 years)hospitalized with laboratory-confirmed dengue in a tertiary center for infectious diseases from 2013 to 2019 in China's Mainland.Serum albumin levels were estimated and compared between patients with severe dengue and non-severe dengue.Additionally,the association between serum albumin levels and severe dengue was evaluated using a generalized linear model[relative risks(RR)].Multivariate logistic regression analysis was performed to identify the potential predictors of severe dengue.Results:Overall,1568 patients were included in this study.Of these patients,34(2.17%)developed severe dengue.The median serum albumin levels were significantly lower in patients with severe dengue than that in those with non-severe dengue(33 g/L vs.37 g/L,P<0.001).After adjustment for age,sex,and comorbidities,hypoalbuminemia(RR 4.877,95%CI 2.193-11.461,P<0.001)was found to be a predictor of severe dengue.Serum albumin levels(OR 1.303,95%CI 1.161-1.462,P<0.001)and age(OR 1.038,95%CI 1.017-1.061,P<0.001)were significant risk factors for severe dengue.The area under the curve for serum albumin levels to distinguish severe dengue was 0.787.Conclusions:Lower serum albumin levels were significantly associated with disease severity in adult patients with dengue.Hypoalbuminemia on admission resulted in at least a four-fold increased risk of severe dengue.

关 键 词：DENGUE Severe dengue Serum albumin HYPOALBUMINEMIA Prediction 

分 类 号：R512.8[医药卫生—内科学]