前列欣胶囊治疗湿热下注型慢性前列腺炎伴勃起功能障碍临床观察  

Clinical observation of Qianliexin capsule on erectile dysfunction in patients with chronic prostatitis of damp-heat type and its effect on

作　　者：郭垣杉 赵帅 李珅 吕姝樾 杨晓鹏 苏世强 张晋 秦彩朋[3] 徐涛[3] GUO Yuanshan;ZHAO Shuai;LI Shen;LV Shuyue;YANG Xiaopeng;SU Shiqiang;ZHANG Jin;QIN Caipeng;XU Tao(Department of Urology,Shijiazhuang Hospital of Peking University People's Hospital,Shijiazhuang Hebei 050030;Department of acupuncture&moxibustion,Shijiazhuang Hospital of Peking University People's Hospital,Shijiazhuang,Hebei 050030;Department of Urology,Peking University People's Hospital,Beijing 100044)

机构地区：[1]北京大学人民医院石家庄医院泌尿外科,河北石家庄050030 [2]北京大学人民医院石家庄医院针灸科,河北石家庄050030 [3]北京大学人民医院泌尿外科,北京100044

出　　处：《河北中医》2023年第6期952-956,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2022年度中医药类科研计划课题(编号:2022185)。

摘　　要：目的 观察前列欣胶囊治疗湿热下注型慢性前列腺炎伴勃起功能障碍的临床效果。方法 将104例湿热下注型慢性前列腺炎伴勃起功能障碍患者按照随机数字表法以1∶1的比例分为治疗组(n=52,脱落4例)和对照组(n=52,脱落5例)。对照组予左氧氟沙星联合坦索罗欣治疗,治疗组在对照组的基础上加前列欣胶囊治疗,连续服用4周。比较2组治疗前后美国国立卫生研究院慢性前列腺炎症状评分量表(NIH-CPSI)评分、国际勃起功能指数-5(IIEF-5)评分、蒙哥马利-艾森贝格抑郁量表(MADRS)评分及前列腺小体外泄蛋白水平变化,比较2组勃起功能障碍疗效和中医证候疗效、不良反应发生率。结果 治疗后2组NIH-CPSI各项评分均较本组治疗前降低,且治疗组疼痛症状、生活质量评分及总分均低于对照组,比较差异均有统计学意义(P<0.05)。治疗后,2组IIEF-5评分均较本组治疗前升高(P<0.05),MADRS评分及前列腺小体外泄蛋白水平均较本组治疗前降低(P<0.05),且治疗组IIEF-5评分高于对照组(P<0.05),前列腺小体外泄蛋白水平低于对照组(P<0.05)。治疗组勃起功能障碍总有效率89.58%(43/48),中医证候总有效率68.75%(33/48),对照组分别为70.21%(33/47)、46.81%(22/47),治疗组均高于对照组(P<0.05)。治疗组不良反应总发生率为12.50%(6/48),对照组为10.64%(5/47),2组比较差异无统计学意义(P>0.05)。结论 前列欣胶囊联合左氧氟沙星、坦索罗欣治疗湿热下注型慢性前列腺炎伴勃起功能障碍患者的治疗效果更佳,能有效缓解患者临床症状,提升生活质量,且不会增加不良反应。Objective To explore the therapeutic effect of Qianliexin Capsule on erectile dysfunction(ED)in patients with chronic prostatitis(CP)of damp-heat type.Methods Totally 104 CP patients with ED(damp-heat type)were enrolled as the study subjects.the patients were randomly in a 1:1 ratio assigned into an observation group(n=52,shedding 4)and a control group(n=52,shedding 5).Patients of the control group was treated with levofloxacin combined with tamsulosin,and patients of the treatment group was additionally treated with Qianliexin capsule,the treatment continued for 4 weeks.The score of National Institutes of Health-Chronic Prostatitis Symptom Index(NIH-CPSI),International Index of Erectile Function-5(IIEF-5),Montgomery-Asberg Depression Rating Scale(MADRS),and the level of prostatic exosomal protein were assessed.The efficacy of ED and traditional Chinese medicine(TCM)syndromes,as well as the incidence of adverse reactions were compared between groups.Results After treatment,the each dimension scores of NIH-CPSI in the two groups were significantly lower than those before treatment(P<0.05),and the scores of pain symptoms,quality of life and total score in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the IIEF-5 scores of the two groups were significantly higher than those before treatment(P<0.05),and the treatment group was significantly higher than the control group(P<0.05).After treatment,the scores of MADRS and the level of prostatic exosomal protein in the two groups were significantly lower compared with those before treatment(P<0.05),and the level of prostatic exosomal protein was significantly lower in the treatment group than in the control group(P<0.05).The total effective rate of ED(89.58%[43/48]vs 70.21%[33/47])and TCM syndromes(68.75%[33/48]vs 46.81%[22/47])in the treatment group were significantly higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the treatment grou

关 键 词：前列腺炎 勃起功能障碍 中医治疗学 

分 类 号：R697.330.531[医药卫生—泌尿科学] R698.2[医药卫生—外科学]