痛痒消洗剂对小儿肛瘘术后创面愈合的影响研究  

Clinical efficacy of Tongyangxiao Lotion on postoperative wound healing in infantile anal fistula

作　　者：徐丹阳 高记华 薛伟彩[2] 孔祥前 李冠路 孙少哲 孙宏远 XU Danyang;GAO Jihua;XUE Weicai;KONG Xiangqian;LI Guanlu;SUN Shaozhe;SUN Hongyuan(Graduate School of Hebei University of Chinese Medicine,Shijiazhuang,Hebei 050091;First Department of Anorectum,the First Affiliated Hospital of Hebei University of Chinese Medicine,Shijiazhuang,Hebei 050011)

机构地区：[1]河北中医学院研究生院,河北石家庄050091 [2]河北中医学院第一附属医院肛肠一科,河北石家庄050011

出　　处：《河北中医》2023年第6期965-969,973,共6页Hebei Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:82174381);河北省中医药管理局2020年度中医药类科研计划课题(编号:2020108)。

摘　　要：目的 观察痛痒消洗剂对小儿肛瘘术后创面愈合的影响。方法 将80例肛瘘患儿按照随机数字表法分为2组,均予常规肛瘘挂线术。治疗组40例术后予痛痒消洗剂熏洗坐浴,对照40例予1∶5000高锰酸钾液熏洗坐浴。治疗14天后比较2组疗效;比较2组创面愈合时间;比较2组术后第3、7、14天创面愈合率、创面分泌物评分、创面肉芽生长评分、创面疼痛评分;比较2组术后第1、14天血清白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平变化。结果 治疗组治愈率90.0%(36/40),对照组治愈率67.5%(27/40),治疗组疗效优于对照组(P<0.05)。治疗组创面愈合时间(18.45±3.15)天,对照组创面愈合时间(23.78±4.08)天,2组创面愈合时间比较差异有统计学意义(P<0.05)。治疗组术后第3、7、14天创面愈合率均高于对照组(P<0.05)。2组术后第3天创面分泌物评分比较差异无统计学意义(P>0.05);2组术后第7、14天创面分泌物评分比较差异有统计学意义(P<0.05)。2组术后第3天创面肉芽生长评分比较差异无统计学意义(P>0.05);2组术后第7、14天创面肉芽生长评分比较差异有统计学意义(P<0.05)。治疗组术后第3、7、14天创面疼痛评分均低于对照组(P<0.05)。2组术后第1天血清IL-6、TNF-α水平比较差异均无统计学意义(P>0.05);2组术后第14天血清IL-6、TNF-α水平均较本组术后第1天降低(P<0.05),且治疗组低于对照组(P<0.05)。结论 痛痒消洗剂促进小儿肛瘘术后创面愈合效果显著。Objective To observe the clinical efficacy of Tongyangxiao Lotion on postoperative wound healing in infantile anal fistula.Methods A total of 80cases of infantile anal fistula were randomly assigned into the treatment group(n=40)and the control group(n=40).All children was managed by conventional anal fistula seton,the treatment group received fumigation-washing sitz bath with Tongyangxiao Lotion,and the control group with routine fumigation sitz bath.On postoperative days 1,3,7,14,the wound healing time,the wound healing rate,wound secretion score,wound granulation growth score,wound pain score,interleukin-6(IL-6),tumor necrosis factor-a(TNF-α),as well we curative effect were included as comparators.Results The cure rate in the treatment group was better compared with the control group(90.0%[36/40]vs 67.5%[27/40],P<0.05).The difference was statistically significant in the wound healing time between the treatment group and the control group([18.45±3.15]d vs[23.78±4.08]d,[P<0.05],respectively).The wound healing rate on postoperative days 3,7,14 was higher in the treatment group than in the control group(P<0.05).The scores of wound secretion and wound granulation growth on postoperative day 3 between groups were comparable(all P>0.05),but there were statistically significant differences in the scores of wound secretion and wound granulation growth on postoperative days 7,14 between groups(all P<0.05).The scores of wound pain on postoperative days 3,7,14 were decreased in the treatment group compared with the control group(P<0.05).None of the IL-6 and TNF-αon postoperative day 1 differed significantly between groups(P>0.05).IL-6 and TNF-αon postoperative day 14 in groups were significantly lower than those on postoperative day 1(P<0.05),and which in the treatment group were significantly lower than the control group(P<0.05).Conclusion Tongyangxiao Lotion has a significant effect on postoperative wound healing in infantile anal fistula.

关 键 词：小儿肛瘘 中医疗法 熏洗疗法 

分 类 号：R726.571.6[医药卫生—儿科] R244[医药卫生—临床医学]