布地奈德雾化吸入治疗小儿急性喉气管支气管炎的效果评价  

Effect evaluation of budesonide aerosol inhalation in the treatment of acute laryngotracheal bronchitis in children

作　　者：史慧 SHI Hui(Pediatrics Department,Shandong Guoxin Yiyang Group Laiwu Central Hospital,Jinan 271103,China)

机构地区：[1]山东国欣颐养集团莱芜中心医院儿科,271103

出　　处：《中国实用医药》2023年第11期105-108,共4页China Practical Medicine

摘　　要：目的评价布地奈德雾化吸入治疗小儿急性喉气管支气管炎的临床效果。方法74例急性喉气管支气管炎患儿,根据随机数字表法分为观察组和对照组,各37例。对照组采用地塞米松静脉滴注治疗,观察组采用布地奈德雾化吸入治疗。对比两组患儿的临床疗效、治疗后症状消失时间及治疗前后炎症指标。结果观察组患儿总有效率94.59%高于对照组的78.38%,差异具有统计学意义(P<0.05)。治疗前,两组患儿白细胞计数、C反应蛋白、降钙素原水平比较差异无统计学意义(P>0.05);治疗后,两组患儿白细胞计数、C反应蛋白、降钙素原水平均低于治疗前,且观察组患儿白细胞计数(6.43±2.44)×10^(9)/L、C反应蛋白(3.26±0.35)mg/L、降钙素原(0.03±0.01)ng/ml均低于对照组的(7.57±1.29)×10^(9)/L、(4.09±0.44)mg/L、(0.05±0.01)ng/ml,差异具有统计学意义(P<0.05)。治疗后,观察组患儿声音嘶哑、咳嗽、发热及咽部水肿消失时间分别为(4.19±1.43)、(3.27±1.47)、(2.46±1.18)、(5.42±1.38)d,均短于对照组的(5.75±1.16)、(4.82±1.25)、(3.74±1.45)、(6.45±1.64)d,差异具有统计学意义(P<0.05)。结论相较于地塞米松静脉滴注治疗,布地奈德雾化吸入治疗小儿急性喉气管支气管炎可显著提高临床效果,症状消失时间明显缩短,值得推广。Objective To evaluate the clinical effect of budesonide aerosol inhalation in the treatment of acute laryngotracheal bronchitis in children.Methods A total of 74 children with acute laryngotracheobronchitis were divided into observation group and control group according to random numerical table,with 37 cases in each group.The control group was treated with dexamethasone intravenous drip,and the observation group was treated with budesonide aerosol inhalation.The clinical efficacy,time of symptom disappearance after treatment,and inflammatory indicators before and after treatment were compared between the two groups.Results The total effective rate of 94.59%in the observation group was higher than that of 78.38%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in leukocyte count,C-reactive protein and procalcitonin levels between the two groups(P>0.05).After treatment,the leukocyte count,C-reactive protein and procalcitonin levels in the two groups were lower than those before treatment in this group;the observation group had leukocyte count of(6.43±2.44)×10^(9)/L,C-reactive protein of(3.26±0.35)mg/L and procalcitonin of(0.03±0.01)ng/ml,which were lower than those of(7.57±1.29)×10^(9)/L,.(4.09±0.44)mg/L and(0.05±0.01)ng/ml in the control group;the differences were statistically significant(P<0.05).After treatment,the disappearance time of hoarseness,cough,fever and pharyngeal edema were(4.19±1.43),(3.27±1.47),(2.46±1.18)and(5.42±1.38)d in the observation group,which were shorter than those of(5.75±1.16),(4.82±1.25),(3.74±1.45)and(6.45±1.64)d in the control group,and the differences were statistically significant(P<0.05).Conclusion Compared with dexamethasone intravenous drip,budesonide aerosol inhalation in the treatment of acute laryngotracheal bronchitis can significantly improve the clinical effect and shorten the time of symptom disappearance,so it is worth promoting.

关 键 词：布地奈德 雾化吸入 小儿急性喉气管支气管炎 地塞米松 

分 类 号：R725.6[医药卫生—儿科]