感冒胶囊质量标准提升研究  

Improvement of the quality standard of Ganmao capsule

作　　者：刘竞 刘东升 朱旭江 王兰霞[1] 高嘉雯 张迈娜 叶青 LIU Jing;LIU Dongsheng;ZHU Xujiang;WANG Lanxia;GAO Jiawen;ZHANG Maina;YE Qing(Gansu University of Chinese Medicine,Lanzhou Gansu 730000,China;Gansu Institute for Drug Control,Lanzhou Gansu 730070,China;State Drug Administration-Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces,Lanzhou Gansu 730070,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省药品检验研究院,甘肃兰州730070 [3]国家药品监督管理局中药材及饮片质量控制重点实验室,甘肃兰州730070

出　　处：《中兽医医药杂志》2023年第3期50-54,共5页Journal of Traditional Chinese Veterinary Medicine

基　　金：甘肃省药品科研项目(2022GSMPA0027)。

摘　　要：补充和完善感冒胶囊质量标准。采用薄层色谱法(TLC)对薄荷进行定性鉴别,采用高效液相色谱法(HPLC)对苦杏仁进行鉴别,采用HPLC法测定感冒胶囊中盐酸麻黄碱和盐酸伪麻黄碱总含量。结果显示,TLC法专属性强,能有效鉴别薄荷药材;HPLC法专属性强,能有效鉴别苦杏仁;盐酸麻黄碱与盐酸伪麻黄碱在各自范围内线性关系良好(r=0.9999),平均回收率为99.0%~103.0%(RSD<3%)。该研究建立的药材鉴别和含量测定方法为提高与完善感冒胶囊质量标准提供了科学依据。To supplement and improve the quality standard of Ganmao capsule,thin layer chromatography(TLC) was used for the qualitative identification of Herb Menthae,Semen Armeniacae Amarum was identified by high performance liquid chromatography(HPLC),HPLC method was used to determine the total content of ephedrine hydrochloride and pseudoephedrine hydrochloride in Ganmao capsule.TLC method was specific and could effectively identify the essential materials of Herb Menthae;HPLC method has strong specificity and can effectively identify Semen Armeniacae Amarum;ephedrine hydrochloride and pseudoephedrine hydrochloride presented a good relationship in their respective linear range(r=0.999 9),and the average recovery was 99.0%-103%(RSD3%).The identification and content determination method established in this study provides a scientific basis for improving the quality standard of Ganmao capsules.

关 键 词：感冒胶囊 薄层色谱 高效液相色谱 含量测定 

分 类 号：S853.7[农业科学—临床兽医学]