前列腺电切术后甲磺酸多沙唑嗪联合双氯芬酸钠治疗术后膀胱痉挛的疗效及安全性  

Clinical efficacy and safety of doxazosin mesylate combined with diclofenac sodium on postoperative bladder spasm after TURP

作　　者：念勇强 陈行祥 NIAN Yong-qiang;CHEN Xing-xiang(Fuqing Second Hospital of Fujian Province,Fuqing 350300,China)

机构地区：[1]福建省福清市第二医院,福清350300

出　　处：《中国新药杂志》2023年第11期1132-1136,共5页Chinese Journal of New Drugs

摘　　要：目的:探究与分析前列腺电切术(electro-prostatectomy, TURP)术后口服甲磺酸多沙唑嗪缓释片联合双氯芬酸钠栓肛塞治疗术后膀胱痉挛的临床疗效及安全性。方法:选取本院2020年3月至2022年5月收治的接受TURP患者110例,采取随机数字表法分为对照组与观察组,每组各55例,对照组实施TURP术后口服甲磺酸多沙唑嗪缓释片治疗,观察组在其基础上加用双氯芬酸钠栓肛塞治疗,对比两组术后膀胱痉挛发生时间及次数、视觉模拟评分法(visual analogue scale, VAS)评分、膀胱冲洗液变淡时间、导管留置时间、术后住院时间以及不良反应发生率。结果:观察组术后0~24 h、术后24~78 h、术后48~72 h分别与对照组术后0~24 h、术后24~78 h、术后48~72 h相比,术后膀胱痉挛发生持续时间较短,术后膀胱痉挛次数较少,VAS评分较低,差异有统计学意义(P<0.05)。观察组与对照组相比术后膀胱冲洗液变淡时间、导管留置时间及术后住院时间均较短,差异有统计学意义(P<0.05)。两组术后不良反应发生率相比,差异无统计学意义(P>0.05)。结论:TURP术后应用甲磺酸多沙唑嗪联合双氯芬酸钠治疗术后膀胱痉挛的效果突出,可有效缩短膀胱痉挛的发生时间,降低发病次数,缓解疼痛程度,缩短各临床症状时间,且用药期间并未增加不良反应,安全性较高。Objective:To explore and analyze the clinical efficacy and safety of doxazosin mesylate sustained release tablets in the treatment of postoperative bladder spasm after electroprostatectomy(TURP).Methods:A total of 110 patients receiving TURP admitted to our hospital from March 2020 to May 2022 were selected and randomly divided into control and observation groups,with 55 cases in each group.The control group was treated with doxazosin mesylate sustained release tablets after TURP operation,and the observation group was treated with diclofenac sodium supposal anal plug on the basis of oral treatment.The results of occurrence time and frequency of postoperative bladder spasm,visual analog scale(VAS),duration of bladder flushing solution dilution,catheter indwelling time,postoperative hospital stay and incidence of adverse reactions were compared between the two groups.Results:In the observation group,the duration of postoperative bladder spasm was shorter,the frequency was less,and the VAS score was lower than that in the control group 0 to 24 h,24 to 78 h and 48 to 72 h after surgery,with statistically significant differences(P<0.05).Compared with the control group,the observation group had a significantly shorter duration of bladder flushing fluid dilution,catheter indwelling time and postoperative hospital stay(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion:The application of doxazosin mesylate combined with diclofenac sodium in the treatment of postoperative bladder spasm after TURP has a singnificant effectwith high safety.It can effectively shorten the occurrence time of bladder spasm,reduce the frequency of incidence,relieve the degree of pain and shorten the duration of clinical symptoms.There is no obvious adverse reactions during medication.

关 键 词：前列腺电切术 甲磺酸多沙唑嗪缓释片 双氯芬酸钠 术后膀胱痉挛 疗效 安全性 

分 类 号：R969.4[医药卫生—药理学]