终末期肾病维持性血液透析患者β2-MG、EOS水平与颈动脉粥样硬化及预后的关系  

Relationship between β2-MG and EOS Levels and Carotid Atherosclerosis and Prognosis in Patients with End-Stage Renal Disease on Maintenance Hemodialysis

作　　者：贺松敏 王宝喜 江杨阳 贾志楠 白保亮 HE Song-min;WANG Bao-xi;JIANG Yang-yang;JIA Zhi-nan;BAI Bao-liang(Department of Clinical Laboratory,Hebei Yanda Hospital,Langfang,Hebei,065200,China;Department of Nephrology,Hebei Yanda Hospital,Langfang,Hebei,065200,China)

机构地区：[1]河北燕达医院检验科,河北廊坊065200 [2]河北燕达医院肾病科,河北廊坊065200

出　　处：《现代生物医学进展》2023年第11期2178-2182,共5页Progress in Modern Biomedicine

基　　金：河北省医学科学研究重点课题计划项目(20191065)。

摘　　要：目的:探讨终末期肾病维持性血液透析(MHD)患者β2微球蛋白(β2-MG)、嗜酸性粒细胞(EOS)计数水平与颈动脉粥样硬化(CAS)及预后的关系。方法:选取2018年1月至2019年6月河北燕达医院收治的121例终末期肾病MHD患者,根据颈动脉粥样硬化发生情况分为CAS组(58例)和无CAS组(63例),检测并比较两组患者的血清β2-MG水平、EOS计数。所有患者出院后随访3年。多因素Logistic回归分析影响终末期肾病MHD患者预后的因素,受试者工作特征(ROC)曲线分析β2-MG、EOS预测终末期肾病MHD患者预后的价值。结果:CAS组血清β2-MG水平,外周血中EOS计数高于无CAS组(P<0.05)。死亡组血清β2-MG水平,外周血中EOS计数高于生存组(P<0.05)。合并CAS、高β2-MG、高EOS计数是终末期肾病MHD患者死亡的危险因素(P<0.05)。β2-MG、EOS联合预测终末期肾病MHD患者预后的曲线下面积为0.904,高于单独指标预测。结论:终末期肾病MHD伴CAS患者血清β2-MG水平和外周血EOS计数增高,且与预后有关,联合检测β2-MG和EOS可提高终末期肾病MHD患者预后的预测效能。Objective:To investigate the relationship betweenβ2 microglobulin(β2-MG)and eosinophilic granulocytes(EOS)count levels and carotid atherosclerosis(CAS)and prognosis in patients with end-stage renal disease on maintenance hemodialysis(MHD).Methods:121 patients with end-stage renal disease on MHD who were admitted to Hebei Yanda Hospital from January 2018 to June 2019 were selected,and they were divided into CAS group(58 cases)and non-CAS group(63 cases)according to the occurrence of carotid atherosclerosis.Serumβ2-MG level and EOS counts in the two groups were detected and compared.All patients were followed up for 3 years after discharge.Multivariate Logistic regression analysis was conducted to analyze the prognostic factors of patients with end-stage renal disease on MHD,and receiver operating characteristic(ROC)curve was used to analyze the prognostic value ofβ2-MG and EOS in patients with end-stage renal disease on MHD.Results:Serumβ2-MG level and peripheral blood EOS count in the CAS group were higher than those in the non-CAS group(P<0.05).Serumβ2-MG level and peripheral blood EOS count in the death group were higher than those in the survival group(P<0.05).Combined with CAS,highβ2-MG and high EOS count were risk factors for death in patients with end-stage renal disease on MHD(P<0.05).The area under curve of combining theβ2-MG and EOS predicted the prognosis of patients with end-stage renal disease on MHD was 0.904,which was higher than that predicted by single indexes.Conclusion:Serumβ2-MG level and peripheral blood EOS count are increased in patients with end-stage renal disease on MHD with CAS,and which are associated with prognosis,the combined detection ofβ2-MG and EOS can improve the predictive efficacy of prognosis in patients with end-stage renal disease on MHD.

关 键 词：终末期肾病 维持性血液透析 颈动脉粥样硬化 Β2-MG EOS 预后 预测效能 

分 类 号：R692[医药卫生—泌尿科学] R459.5[医药卫生—外科学]