干细胞治疗雄激素脱发的研究进展  

Advances in stem cells treatment of androgenetic alopecia

作　　者：晏文静 刘建兴 金亮[1] YAN Wenjing;LIU Jianxing;JIN Liang(School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学生命科学与技术学院,南京211198

出　　处：《中国药科大学学报》2023年第3期372-379,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81570696);国家“863”计划项目资助项目(No.2015AA020314);江苏省杰出青年基金资助项目(No.BK20140029)。

摘　　要：雄激素性脱发(androgenetic alopecia,AGA)是最常见的进行性脱发。目前,药物治疗是治疗AGA的主要方法,然而,药物治疗具有明显的副作用。干细胞具有组织修复和维持微环境稳态的作用,可为治疗AGA提供新策略。本文综述了AGA的发病机制,探讨了传统药物治疗的缺陷,同时论述了干细胞及干细胞衍生物在治疗AGA中的研究进展,以期全面反映干细胞治疗AGA的前景。Androgenetic alopecia(AGA)is the most prominent type of progressive hair loss in humans.At pres⁃ent,medication is the main treatment for AGA,however,drug therapy has significant side-effects.Stem cells pro⁃vide a new strategy for the treatment of AGA,because of their role in tissue repair and maintenance of microenvi⁃ronmental homeostasis.This paper reviews the pathogenesis of AGA,discusses the defects of traditional drug therapy,and discusses the research progress of stem cells and stem cell derivatives in the treatment of AGA,in or⁃der to provide a comprehensive review of the prospects of stem cell therapy for AGA.

关 键 词：雄激素脱发 干细胞治疗 干细胞衍生物 机制 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]