经颅直流电刺激对心理旋转的事件相关电位影响研究  

Effects of transcranial direct current stimulation on event-related potentials of mental rotation

作　　者：李佳艺 张力新[1] 柯余峰 明东 LI Jiayi;ZHANG Lixin;KE Yufeng;MING Dong(School of Precision Instrument and Opto-Electronics Engineering,Tianjin University,Tianjin 300072,P.R.China;Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,P.R.China)

机构地区：[1]天津大学精密仪器与光电子工程学院生物医学工程系,天津300072 [2]天津大学医学工程与转化医学研究院生物医学工程系,天津300072

出　　处：《生物医学工程学杂志》2023年第3期434-441,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81741139)。

摘　　要：目前,经颅直流电刺激对复杂空间认知的调控作用的研究较少,特别是经颅直流电刺激对空间认知过程中的神经电生理响应的影响规律尚不明确。本研究以经典的空间认知任务范式(三维心理旋转任务)为研究对象,通过对比不同经颅直流电刺激模式下的行为学和事件相关电位在经颅直流电刺激施加前、中、后的变化,分析经颅直流电刺激对心理旋转的行为学和神经电生理影响。真、伪经颅直流电刺激模式间的对比表明,行为学在不同刺激模式间的差异无统计学意义,但事件相关电位P2、P3幅值在刺激过程中的变化具有统计学意义。相对伪刺激模式,真刺激模式下事件相关电位P2、P3幅值表现出更大的降低幅度。本研究阐明了经颅直流电刺激对心理旋转任务的事件相关电位的影响规律,表明经颅直流电刺激可能提高了心理旋转任务过程中的大脑信息处理效率,为深入理解和探索经颅直流电刺激对复杂空间认知的调控作用提供参考。There are few researches on the modulation effect of transcranial direct current stimulation(tDCS)on complex spatial cognition.Especially,the influence of tDCS on the neural electrophysiological response in spatial cognition is not yet clear.This study selected the classic spatial cognition task paradigm(three-dimensional mental rotation task)as the research object.By comparing the changes in behavior and event-related potentials in different modes of tDCS before,during and after the application of tDCS,this study analyzed the behavioral and neurophysiological effects of tDCS on mental rotation.The comparison between active-tDCS and sham-tDCS showed no statistically significant difference in behavior between different stimulation modes.Still,the changes in the amplitudes of P2 and P3 during the stimulation were statistically significant.Compared with sham-tDCS,the amplitudes of P2 and P3 in active-tDCS mode showed a greater decrease during the stimulation.This study clarifies the influence of tDCS on the event-related potentials of the mental rotation task.It shows that tDCS may improve the brain information processing efficiency during the mental rotation task.Also,this study provides a reference for an in-depth understanding and exploration of the modulation effect of tDCS on complex spatial cognition.

关 键 词：经颅直流电刺激 心理旋转 事件相关电位 神经效率 

分 类 号：R318[医药卫生—生物医学工程]