生物可降解锌合金作为骨植入材料的研究现状和进展  

Research status and development of biodegradable zinc alloy as orthopedics implant

作　　者：张天蔚(综述) 刘宇宸(综述) 王韦丹(综述) 赵德伟(审校) ZHANG Tianwei;LIU Yuchen;WANG Weidan;ZHAO Dewei(College of Mechanical Engineering,Dalian Jiaotong University,Dalian,Liaoning 116028,P.R.China;Department of Orthopedics,Affiliated Zhongshan Hospital of Dalian University,Dalian,Liaoning 116001,P.R.China)

机构地区：[1]大连交通大学机械工程学院,辽宁大连116028 [2]大连大学附属中山医院骨科,辽宁大连116001

出　　处：《生物医学工程学杂志》2023年第3期589-594,601,共7页Journal of Biomedical Engineering

基　　金：国家骨科与运动康复临床医学研究中心创新基金(2021-NCRC-CXJJ-ZH-28)。

摘　　要：锌(Zn)合金具有良好的细胞相容性和适宜的降解速率,是一种极具临床应用前景的生物可降解金属。本文总结了可降解Zn合金作为骨植入材料的生物学作用,归纳了不同Zn合金材料的力学性能及其作为骨植入材料的优缺点,分析了不同加工策略(如合金化、增材制造等)对Zn合金力学性能的影响。全文从材料选择、产品加工处理及结构拓扑优化等方面为生物可降解Zn合金骨植入材料提供了系统化的设计思路,并对其应用前景进行了展望,以期更好地服务于临床。Znic(Zn)alloys with good cytocompatibility and suitable degradation rate have been a kind of biodegradable metal with great potential for clinical applications.This paper summarizes the biological role of degradable Zn alloy as bone implant materials,discusses the mechanical properties of different Zn alloys and their advantages and disadvantages as bone implant materials,and analyzes the influence of different processing strategies(such as alloying and additive manufacturing)on the mechanical properties of Zn alloys.This paper provides systematic design approaches for biodegradable Zn alloys as bone implant materials in terms of the material selection,product processing,structural topology optimization,and assesses their application prospects with a view to better serve the clinic.

关 键 词：锌合金 机械性能 合金化 增材制造 骨植入材料 

分 类 号：R318.08[医药卫生—生物医学工程]