慢性肾脏病与甲状腺功能相关性的Meta分析  

A Meta-analysis of the Correlation Between Chronic Kidney Disease and Thyroid Function

作　　者：李炬楠 邹媛媛 刘静[1] 史应进[2] LI Junan;ZOU Yuanyuan;LIU Jing;SHI Yingjin(Inner Mongolia University of Scienee and Technology,Medical Conege of Baotou,Baotou 014040 China;Department of Nephrology,The First Affiliated Hospital,Inner Mongolia University of Science and Technology Baotou Medical College,Baotou 014010 China)

机构地区：[1]内蒙古科技大学包头医学院研究生学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院肾内科,内蒙古包头014010

出　　处：《内蒙古医学杂志》2023年第4期455-458,465,共5页Inner Mongolia Medical Journal

摘　　要：目的系统评价慢性肾脏病(Chronic Kidney Disease,CKD)与甲状腺功能之间的关系,为延缓CKD患者肾小球滤过率(Glomerular Filtration Rate,GFR)下降提供循证医学证据。方法通过计算机检索Pubmed、Embase、Medline和中国知网4个数据库,检索时间为2012—2022年。由2名独立的研究人员根据纳入和排除标准筛选文献、提取研究数据。采用Review Manager 5.4.1进行Meta分析。结果共纳入研究6个,样本量37566例。与对照组比较:(1)以促甲状腺激素(Thyroid Stimulating Hormone,TSH)为研究对象,CKD组肾小球滤过率水平更高,差异有统计学意义[SMD=0.49,95%CI(0.04,0.94);Z=2.14,P<0.05];(2)以游离甲状腺激素(Free Thyroxine,FT4)为研究对象,结果不明显,差异无统计学意义[SMD=0.05,95%CI(-0.10~0.20);Z=0.61,P>0.05]。结论CKD患者TSH水平更高,TSH与CKD风险密切相关,而FT4与CKD风险无关。Objective To analyze the relationship between Chronic Kidney Disease and thyroid function,in order to provide evidence based medical evidence for delaying the Glomerular Filtration Rate GFR in CKD patients.Methods Four databases including Pubmed,Embase,Medline and CNKI were searched by computer from 2012 to 2022.Two independent researchers screened the literature and extracted the study data according to inclusion and exclusion criteria.Meta analysis was performed using Review Manager5.4.1.Results A total of 6 studies were in⁃cluded,with a sample size of 37566 cases.Compared with the control group,(1)The Thyroid Stimulating Hormone TSH was the object of study,the level of thyroid stimulating hormone TSH in CKD group was higher,and the differ⁃ence was statistically significant[SMD=0.49,95%CI(0.04,0.94);Z=2.14,P<0.05];②The Free Thyroxine FT4 was the research object,the results were not obvious and there was no statistical significance[SMD=0.05,95%CI(-0.10,0.20);Z=0.61,P>0.05].Conclusion At baseline,TSH level was higher in CKD patients,and TSH was negatively correlated with the risk of CKD,while FT4 was not.

关 键 词：慢性肾脏病 甲状腺激素 甲状腺功能 META分析 

分 类 号：R692.5[医药卫生—泌尿科学]