鼻腔鼻窦窦组织细胞增生症伴巨大淋巴结病的临床病理特征分析  

Analysis of clinicopathological features of sinus histiocytosis with massive lymphadenopathy

作　　者：周雪筠[1] 袁虎[1] 陈雷[1] 王荣光[1] 刘穹[1] 陈薇 袁静 ZHOU Xuejun;YUAN Hu;CHEN Lei;WANG Rongguang;LIU Qiong;CHEN Wei;YUAN Jing(College of Otolaryngology Head and Neck Surgery,Chinese PLA General Hospital,National Key Labortary of Hearing and Balance Science,National Clinical Research Center for Otolaryngologic Diseases,State Key Lab of Hearing Science,Ministry of Education,Beijing Key Lab of Hearing Impairment Prevention and Treatment,Beijing 100853,China;Department of Pathology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院,耳鼻咽喉头颈外科医学部,听觉与平衡觉全国重点实验室,国家耳鼻咽喉疾病临床医学研究中心,聋病教育部重点实验室,聋病防治北京市重点实验室,北京100853 [2]中国人民解放军总医院第一医学中心病理科,北京100853

出　　处：《中国耳鼻咽喉颅底外科杂志》2023年第3期77-80,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的 探讨发生在鼻腔鼻窦的窦组织细胞增生症伴巨大淋巴结病(SHML)的临床、病理特征。方法 报道3例鼻腔鼻窦SHML患者的临床资料,总结分析其临床病理特征并进行相关文献复习。结果 发生在鼻腔鼻窦的SHML临床以鼻塞为主。病理组织学特点为在淋巴、浆细胞背景下,可见弥漫浸润的窦组织细胞,局部见“封入”现象。免疫组织化学染色示肿瘤细胞表达CD68、S-100。结论 SHML是一种组织细胞增生性病变,发生在鼻腔鼻窦的SHML非常罕见,临床表现缺乏特异性。病理学诊断为金标准,以手术治疗为主,但效果不佳。Objective To analyze the clinical and pathological features of sinus histiocytosis with massive lymphadenopathy(SHML)in the nasal cavity and paranasal sinus.Methods The clinical data and clinicopathological features of 3 patients with SHML were reported and reviewed.Results Nasal congestion is a mainly symptom of the clinical features of SHML.The phenomenon of“sealing”was observed in the sinus histiocytes with diffuse infiltration of lymph and plasma cells,which was a histopathological feature of SHML.Immunohistochemical staining showed expressions of CD68 and S-100 in tumor cells.Conclusions SHML is a kind of histiocytoproliferative lesion.SHML occurring in the nasal sinuses is very rare and its clinical manifestations lack specificity.The pathological diagnosis is the gold standard and SHML is mainly treated by surgery,but its curative effect is poor.

关 键 词：鼻腔 鼻窦 窦组织细胞增生症伴巨大淋巴结病 治疗 

分 类 号：R765.2[医药卫生—耳鼻咽喉科] R765.4[医药卫生—临床医学]