钌化合物抗微生物应用研究进展  

Research Progress on Antimicrobial Application of Ruthenium Complexes

作　　者：聂鹏 董睿 许波[1] NIE Peng;DONG Rui;XU Bo(Guizhou Institute for Food and Drug Control,Guiyang 550004,China)

机构地区：[1]贵州省食品药品检验所,贵州贵阳550004

出　　处：《化学试剂》2023年第7期57-65,共9页Chemical Reagents

基　　金：黔科合基础-ZK[2021]一般041。

摘　　要：了解新报道的钌化合物抗微生物应用,探究其构效关系。分析近年来已报道的钌化合物抗微生物应用文献,总结其可能发展规律。据文献总结,钌化合物可作用于细胞外膜或者细胞内的核酸,以达到抑菌或抗菌的效果。钌化合物的脂溶性、其骨架支撑配体的电子性质和化合物整体的电荷属性都是影响其抗微生物活性的重要因素,仿生配体的配位与解离能显著提高钌化合物的生物活性和相容性,研究热点也聚焦于纳米钌粒子的绿色合成和生物活性成分应激释放。抗微生物类钌化合物的研究朝着绿色、环保、低毒、高效的方向发展,为后续的深入研究提供了一定参考。Learning about newly reported antimicrobial applications of ruthenium compounds and exploring their intrinsic structure-activity relationship is one of the research goals.The reported literatures on antimicrobial application of ruthenium compounds in recent years were analyzed,and the possible development rule were summarized.According to the literature summary,ruthenium compounds can act on the outer membrane or intracellular nucleic acids to achieve bacteriostatic or antibacterial effects.The lipophilicity of ruthenium compounds,the electronic properties of their backbone support ligands,and the overall charge properties are all important factors affecting their antimicrobial activity.In addition,the coordination and dissociation of biomimetic ligands can significantly improve the biological activity and compatibility of ruthenium compounds,and recent research hotspots focus on the green synthesis of nanoruthenium particles and the stress release of bioactive ingredients.The research of antibacterial ruthenium compounds is developing towards the direction of green and environmentally friendliness,low toxicity and high efficiency,providing references for further research.

关 键 词：钌化合物 抗微生物 构型 机制 作用效果 

分 类 号：O627.8[理学—有机化学]