荧光分子探针检测甲醛的研究进展  

Research Progress in the Detection of Formaldehyde by Fluorescent Molecular Probe

作　　者：孙萌[1] 马杰[1] SUN Meng;MA Jie(School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200000,China)

机构地区：[1]上海理工大学材料与化学学院,上海200000

出　　处：《化学试剂》2023年第7期72-77,共6页Chemical Reagents

摘　　要：甲醛,作为重要的醛基小分子原料,被广泛应用于化工、生物医药、建材等领域。过量甲醛严重时可导致基因突变或癌变。系统地综述了近年来基于2-aza-Cope重排、肼醛缩合、胺醛缩合的反应型荧光探针分子的代表性成果。根据聚集态物质的荧光特点将其分为ACQ型、AIE型和MOF材料3类,从探针分子的设计、机制和应用的方面进行系统介绍,归纳这3种类型甲醛荧光探针的优势以及不足。对甲醛荧光探针的未来发展进行了展望,以期为设计性能更优良的荧光探针提供有益参考。As an important aldehyde-based small molecule raw material,formaldehyde is widely used in chemical industry,biomedicine,building materials and other fields.Excessive formaldehyde can lead to gene mutation or cancer in severe cases.The representative results of reactive fluorescent probe molecules based on 2-aza-Cope rearrangement,hydrazine and aldehyde condensation,and amine and aldehyde condensation were reviewed in recent years.According to the fluorescence characteristics of aggregates,they are divided into ACQ,AIE and MOF materials.The advantages and disadvantages of three types of formaldehyde fluorescence probes were summarized from the aspects of the design,mechanism and application of probe molecules.The future development of formaldehyde fluorescent probes was prospected in order to provide useful reference for the design of better fluorescence probes.

关 键 词：甲醛 小分子荧光探针 2-aza-Cope重排 亚胺 AIE效应 

分 类 号：O625.6[理学—有机化学]