降香檀叶化学成分研究  

Chemical Constituents from Leaves of Dalbergia odorifera

作　　者：申晨晓 邵峰 张普照 洪舟[2] 刘荣华 唐芳瑞 范胜贤 SHEN Chen-xiao;SHAO Feng;ZHANG Pu-zhao;HONG Zhou;LIU Rong-hua;TANG Fang-rui;FAN Sheng-xian(Jiangxi University of Chinese Medicine/Key Laboratory of Modern Preparation of TCM,Ministry of Education,Nanchang 330004,China;Research Institute of Tropical Forestry,Chinese Academy of Forestry,Guangzhou 510520,China)

机构地区：[1]江西中医药大学/现代中药制剂教育部重点实验室,江西南昌330004 [2]中国林业科学研究院热带林业研究所,广东广州510520

出　　处：《中药材》2022年第11期2607-2613,共7页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金项目(82160732,82160733,82100417);江西省自然科学基金项目(20202BABL216072);江西省中医药管理局科技计划项目(2019A025)。

摘　　要：目的:研究降香檀Dalbergia odorifera T.Chen叶的化学成分。方法:采用硅胶柱色谱、Sephadex LH-20葡聚糖凝胶柱色谱及制备液相色谱等方法进行分离纯化,并通过理化性质与光谱数据进行结构鉴定。结果:从降香檀叶70%乙醇提取物中分离得到24个化合物,分别鉴定为:鹰嘴豆芽素A(1)、邻苯二甲酸二丁酯(2)、二十八烷醇(3)、羽扇豆醇(4)、5-羟基-4′,7-二甲氧基异黄酮(5)、二甲基鸢尾苷元(6)、7-O-methyltectorigenin(7)、金色酰胺醇酯(8)、单棕榈酸甘油(9)、鸢尾苷(10)、5,7-二羟基色原酮(11)、伞形花内酯(12)、irilin D(13)、樱黄素(14)、东莨菪亭(15)、鸢尾苷元(16)、去氢吐叶醇(17)、黑麦草内酯(18)、3β-羟基-5α,6α-环氧-7-大柱香波龙烯-9-酮(19)、(+)-丁香脂素(20)、10,16-dihydroxyhexadecanoic acid(21)、(+)-丁香脂素-O-β-D-吡喃葡萄糖苷(22)、鸢尾苷元-7-O-β-D-呋喃芹糖基-(1→6)-β-D-吡喃葡萄糖苷(23)、(+)-isolariciresinol-3α-O-β-D-glucopyranoside(24)。结论:其中,化合物8、11、13、18~21、24为首次从黄檀属植物中分离得到,化合物2~7、12、16、17、22、23为首次从该植物中分离得到。Objective:To study the chemical constituents from the leaves of Dalbergia odorifera.Methods:The chemical constituents were isolated and purified by silica gel column chromatography,Sephadex LH-20 column chromatography and preparation of liquid phase and other chromatography techniques,and the structures were identified by physicochemical properties and spectral analysis.Results:Twenty-four compounds were isolated from 70% ethanol extract of Dalbergia odorifera leaves and identified as biochanin A(1),dibutyl phthalate(2),octacosanol(3),lupeol(4),5-hydroxy-4′,7-dimethoxyisoflavone(5),dimethyltectorigenin(6),7-O-methyltectorigenin(7),aurantiamide acetate(8),glycerol monopalmitate(9),tectoridin(10),5,7-dihydroxychromone(11),umbelliferone(12),irilin D(13),prunetin(14),scopoletin(15),tectorigenin(16),dehydrovomifoliol(17),loliolide(18),3β-hydroxy-5α,6α-epoxy-7-megastimen-9-one(19),(+)-syringaresinol(20),10,16-dihydroxyhexadecanoic acid(21),(+)-syringaresinol-O-β-D-glucopyranoside(22),tectorigenin-7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(23),(+)-isolariciresinol-3α-O-β-D-glucopyranoside(24),respectively.Conclusion:Among them,compounds 8,11,13,18 to 21,24 are isolated from the Dalbergia genus for the first time,compounds 2,7,12,16,17,22,23 are isolated from Dalbergia odorifera for the first time.

关 键 词：降香檀叶 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]