八角枫乙酸乙酯部位化学成分的研究  

Chemical Constituents from Ethyl Acetate Fraction of Alangium chinense

作　　者：黄焦艳 肖婷 郭正红 周丽玲 龙庆德 沈祥春[1,2] 陈妍 HUANG Jiao-yan;XIAO Ting;GUO Zheng-hong;ZHOU Li-ling;LONG Qing-de;SHEN Xiang-chun;CHEN Yan(College of Pharmacy,Guizhou Medical University,Guiyang 550025,China;Engineering Center for Efficient Utilization of Natural Medicine Resources/Key Laboratory of Optimal Utizational of Natural Medicinal Resources,Guiyang 550025,China;College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China)

机构地区：[1]贵州医科大学药学院,贵州贵阳550025 [2]贵州省天然药物资源高效利用工程中心/贵州医科大学天然药物资源优效利用重点实验室,贵州贵阳550025 [3]贵州中医药大学药学院,贵州贵阳550025

出　　处：《中药材》2022年第11期2614-2618,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金项目(81760725);国家自然科学基金喀斯特中心项目(U1812403-4-4);贵州省基础研究计划(科学技术基金)(黔科合基础-ZK[2021]一般535);贵州医科大学国家自然基金培育项目(19NSP074)。

摘　　要：目的:研究八角枫Alangium chinense(Lour.)Harms须根乙酸乙酯部位的化学成分。方法:采用正相硅胶色谱、Toyopearl HW-40F凝胶柱色谱及半制备高效液相色谱等技术进行分离纯化,通过理化性质、核磁波谱数据分析及参考文献鉴定化合物结构。结果:从八角枫须根乙酸乙酯部位中分离得到了17个化合物,分别鉴定为:球松素(1)、dibutylphthalate(2)、花椒油素(3)、豆甾醇(4)、莫雷亭酮(5)、豆甾-4-烯-3-酮(6)、β-谷甾醇(7)、24-乙基胆甾-3,6-二酮(8)、7-羟基-3′,4′-二氧亚甲基异黄酮(9)、hibiscolactone(10)、水杨酸(11)、D-艾杜糖醇(12)、胡萝卜苷(13)、(3E,23E)-dicoumaroylhederagenin(14)、丁香酸(15)、没食子酸乙酯(16)、uracil(17)。结论:其中,化合物1~3、5、8~10、12、15为首次从该属植物中分离得到。Objective:To study the chemical constituents from the ethyl acetate fraction of Alangium chinense fibrous roots.Methods:The chemical constituents were isolated and purified by chromatographies with silica gel,Toyopearl HW-40F and semi-preparative high performance liquid chromatography.The structures were identified by physicochemical properties,spectroscopic data and relevant references.Results:Seventeen compounds were isolated from the ethyl acetate layer of Alangium chinense fibrous roots and identified as pinostrobin(1),dibutylphthalate(2),xanthoxylin(3),stigmasterol(4),moretenone(5),sitostenone(6),β-sitosterol(7),24-ehylcholesta-3,6-dione(8),7-hydroxy-3′,4′-methylenedioxyisoflavone(9),hibiscolactone(10),salicylic acid(11),D-iditol(12),daucosterol(13),(3E,23E)-dicoumaroylhederagenin(14),syringic acid(15),ethyl-gallate(16),uracil(17),respectively.Conclusion:Among them,compounds 1 to 3,5,8 to 10,12,15 are isolated from Alangium genus for the first time.

关 键 词：八角枫须根 乙酸乙酯层 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]