川芎中促进视网膜血管内皮细胞增殖的化学成分  

Study on Chemical Constituents Promoting the Proliferation of Retinal Vascular Endothelial Cells of Ligusticum chuanxiong

作　　者：徐倩倩 周梅林 赵苏敏 肖琴文 沈琳琳 许少英 董建勇 XU Qian-qian;ZHOU Mei-lin;ZHAO Su-min;XIAO Qin-wen;SHEN Lin-lin;XU Shao-ying;DONG Jian-yong(College of Pharmacy,Wenzhou Medical University,Wenzhou 325035,China)

机构地区：[1]温州医科大学药学院,浙江温州325035

出　　处：《中药材》2022年第11期2643-2647,共5页Journal of Chinese Medicinal Materials

摘　　要：目的:研究川芎中促进视网膜血管内皮细胞增殖的有效成分。方法:采用现代分离和波谱技术纯化鉴定化合物。结果:从川芎提取物中分离得到了14个化合物,分别鉴定为:苄基-β-D-吡喃葡萄糖苷(1)、咖啡酸甲酯(2)、胸腺嘧啶脱氧核苷(3)、(Z)-6,7-环氧藁苯内酯(4)、3-羟基-4-甲氧基肉桂酸(5)、homosenkyunolide H(6)、洋川芎内酯I(7)、4-羟基-3-甲氧基苯甲醛(8)、1-阿魏酰氧基-2-甲氧基肉桂酸(9)、洋川芎内酯H(10)、4-戊基环己基-3-烯-1α,2β-二醇(11)、反式咖啡酸乙酯(12)、反式阿魏酸(13)和(4S,5S)-5-hydroxy-4-hexanolide(14)。结论:其中,化合物1、6、9、12、14为首次从川芎中分离得到。化合物2、4~6、9、10、12对RF/6A细胞的增殖具有明显的促进作用。Objective:To study the effective components promoting the proliferation of retinal vascular endothelial cells of Ligusticum chuanxiong.Methods:Modern separation and spectral techniques were used to purify and identify the compounds.Results:Fourteen compounds were isolated from the extract of Ligusticum chuanxiong and identified as benzyl-β-D-glucopyranoside(1),caffeic acid methyl ester(2),thymidine(3),(Z)-6,7-epoxyligustilide(4),3-hydroxy-4-methoxycinnamic acid(5),homosenkyunolide H(6),senkyunolide I(7),4-hydroxy-3-methoxy benzal dehyde(8),1-feruloyloxy-2-methoxy cinnamic acid(9),senkyunolide H(10),4-pentylcyclohex-3-ene-1α,2β-diol(11),ethyl trans-3,4-dihydroxycinnamate(12),trans-ferulic acid(13),(4S,5S)-5-hydroxy-4-hexanolide(14),respectively.Conclusion:Among them,compounds 1,6,9,12 and 14 are isolated from Ligusticum chuanxiong for the first time.Compounds 2,4 to 6,9,10,12 have obvious promoting effects on the proliferation of RF/6A cells.

关 键 词：川芎 化学成分 血管内皮细胞增殖作用 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]