血清干扰素-γ与白细胞介素-4及其比值对妊娠期糖尿病患者围产儿不良结局的预测效能  

Prediction efficacy of serum interferon-γ,interleukin-4 and interferon-γ/interleukin-4 ratio on adverse outcome of the perinatal infants of patients with gestational diabetes mellitus

作　　者：张娟 孟祥楠 单锦妹 王浩[1] 崔月清[1] 朱晓琴[1] Zhang Juan;Meng Xiangnan;Shan Jinmei;Wang Hao;Cui Yueqing;Zhu Xiaoqin(Department of Gynaecology and Obstetrics,Yancheng Third People′s Hospital,Yancheng 224000,China)

机构地区：[1]盐城市第三人民医院妇产科,盐城224000

出　　处：《中国临床实用医学》2023年第2期60-63,共4页China Clinical Practical Medicine

摘　　要：目的探讨血清干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及IFN-γ/IL-4比值对妊娠期糖尿病(GDM)患者围产儿不良结局的预测效能。方法本研究为病例对照研究,选取2020年1月年2022年1月盐城市第三人民医院妇产科收治的110例GDM患者的临床资料作为GDM组,年龄(31.69±5.17)岁,年龄范围为20~42岁。选取同期在盐城市第三人民医院门诊定期产检的94例健康孕妇的资料作为健康组,年龄(30.56±4.89)岁,年龄范围为20~41岁。收集两组纳入者分娩前血清IFN-γ、IL-4水平及IFN-γ/IL-4比值,围产儿不良结局发生率。根据GDM组患者的结局分为良好结局亚组和不良结局亚组,并比较两组产儿的母体血清IFN-γ、IL-4水平及IFN-γ/IL-4比值。结果GDM组IL-4水平[(10.69±2.53)pg/ml]低于健康组[(11.98±3.20)pg/ml],IFN-γ[(38.95±10.63)pg/ml]和IFN-γ/IL-4(3.64±0.76)、围产儿总不良结局发生率[18.2%(20/110)]均高于健康组[(20.45±6.71)pg/ml、(1.71±0.52)、5.3%(5/94)],差异有统计学意义(P<0.05);不良结局亚组母体IFN-γ[(52.72±8.62)pg/ml]和IFN-γ/IL-4[(7.48±1.75)]均高于良好结局亚组[(35.89±7.12)pg/ml、(3.12±0.69)],差异有统计学意义(P<0.05);IL-4水平[(7.05±2.46)pg/ml]低于良好结局亚组[(11.50±2.75)pg/ml],差异有统计学意义(P<0.05);IFN-γ、IL-4、IFN-γ/IL-4三者联合的灵敏度、特异度、曲线下面积均高于单独预测。结论血清IFN-γ、IL-4、IFN-γ/IL-4对GDM患者围产儿不良结局有良好的预测效能。Objective To investigate the prediction efficacy of serum interferon-γ(IFN-γ),interleukin-4(IL-4),IFN-γ/IL-4 ratio on adverse outcome of the perinatal child of patients with gestational diabetes mellitus(GDM).Methods This study was a case-control study.Clinical data of 110 patients with GDM admitted to the department of Obstetrics and Gynecology of Yancheng Third People′s Hospital from January 2020 to January 2022 were selected as the GDM group,aged(31.69±5.17)years old,ranging from 20 to 42 years old.A total of 94 healthy pregnant women,aged(30.56±4.89)years old,ranging from 20 to 41 years old,were selected as the healthy group.The serum levels of IFN-γand IL-4 and IFN-γ/IL-4 ratio before delivery were collected,and the incidence of adverse outcomes in perinatal infants.According to the outcome of GDM group,the patients were divided into good outcome subgroup and bad outcome subgroup,and the maternal serum levels of IFN-γ,IL-4 and IFN-γ/IL-4 ratio were compared between the two groups.Results The level of IL-4 in GDM group[(10.69±2.53)pg/ml]was lower than that in healthy group[(11.98±3.20)pg/ml].IFN-γ[(38.95±10.63)pg/ml],IFN-γ/IL-4(3.64±0.76)and the incidence of perinatal adverse outcomes[18.2%(20/110)]were higher than those in healthy group[(20.45±6.71)pg/ml,(1.71±0.52),5.3%(5/94)],the difference was statistically significant(P<0.05);Both IFN-γ[(52.72±8.62)pg/ml]and IFN-γ/IL-4[(7.48±1.75)]in the poor outcome group were higher than those in the good outcome group[(35.89±7.12)pg/ml,(3.12±0.69)],and the difference was statistically significant(P<0.05).IL-4 level[(7.05±2.46)pg/ml]was lower than that of good outcome group[(11.50±2.75)pg/ml],and the difference was statistically significant(P<0.05).The combined sensitivity,specificity and area under the curve of IFN-γ,IL-4 and IFN-γ/IL-4 were all higher than those predicted separately.Conclusions Serum IFN-γ,IL-4 and IFN-γ/IL-4 can predict the adverse outcome of perinatal infants in patients with GDM.

关 键 词：妊娠期糖尿病 围产儿 不良结局 干扰素-Γ 白细胞介素-4 

分 类 号：R714.256[医药卫生—妇产科学]