可溶性髓样细胞触发受体-1在新生儿败血症中的研究进展  

Research progress of soluble form of triggering receptors expressed on myeloid cells-1 in neonatal septicemia

作　　者：卢亚男 万君 张晓梅 LU Ya-nan;WAN Jun;ZHANG Xiao-mei(Inner Mongolia Medical University,Huhhot 010020,China;不详)

机构地区：[1]内蒙古医科大学,内蒙古自治区呼和浩特010020 [2]内蒙古民族大学附属医院,内蒙古自治区通辽028000 [3]内蒙古自治区人民医院,内蒙古自治区呼和浩特010017

出　　处：《中国实用儿科杂志》2023年第5期391-394,共4页Chinese Journal of Practical Pediatrics

摘　　要：新生儿败血症是新生儿期常见的重症感染性疾病,其病情进展迅速,是新生儿期死亡的重要原因。可溶性髓样细胞触发受体-1(soluble form of triggering receptors expressed on myeloid cell-1,sTREM-1)是髓样细胞触发受体-1(triggering receptors expressed on myeloid cell-1,TREM-1)的可溶性亚型,在炎症反应中高度表达,与多种细胞受体协同作用可激活细胞通路及放大炎症反应。大量研究证实sTREM-1在新生儿败血症的早期识别、病情进展及预后评估方面具有重要作用。该文对sTREM-1的生物学特性、信号通路及在新生儿败血症中的作用进行综述。Neonatal septicemia is a common severe infectious disease,which progresses rapidly and is an important cause of death in the neonatal period.Soluble form of Triggering Receptors Expressed on Myeloid cell-1(sTREM-1)is a soluble subtype of Triggering Receptors Expressed on Myeloid cell-1(TREM-1),which is highly expressed in inflammatory response.It can activate cell pathways and amplify inflammatory response by collaborating with multiple cell receptors.Sufficient evidence has confirmed that sTREM-1 plays an important role in the early recognition,disease progression and prognosis evaluation of neonatal septicemia.This article will review the biological characteristics,signal pathway and role of sTREM-1 in neonatal septicemia.

关 键 词：可溶性髓样细胞触发受体-1 新生儿败血症 生物标志物 

分 类 号：R72[医药卫生—儿科]