合成高分子材料和天然高分子材料在硬脑膜修复中的应用进展  

Application progress in synthetic and natural polymer materials for dural membrane repair

作　　者：杨智炫 林越威 张瑗 陈咏梅 张其清 Yang Zhixuan;Lam Yuet-wai;Zhang Yuan;Chen Yongmei;Zhang Qiqing(Shaanxi University of Science and Technology,Xi’an 710021,China;GTR Biotechnology Co.,Ltd.,Fuzhou 350108,China;Fujian Bote Biotechnology Co.,Ltd.,Fuzhou 350011,China;Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]陕西科技大学,西安710021 [2]福建吉特瑞生物科技有限公司,福州350108 [3]福建省博特生物科技有限公司,福州350011 [4]中国医学科学院,北京协和医学院生物医学工程研究所,天津300192

出　　处：《国际生物医学工程杂志》2023年第2期156-162,共7页International Journal of Biomedical Engineering

基　　金：国家重点研发计划"政府间国际科技创新合作"重点专项项目(2022YFE0104200);"十三五"国家重点研发计划项目(2017YFC1103601、2017YFC1104102);福建省科技型中小企业创新资金项目(2018C0102);福建省对外合作项目(2018I0024);陕西省科技厅重点研发计划-国际科技合作计划项目(2020KWZ-006)。

摘　　要：硬脑膜是位于脑表面和颅骨内面之间的双层坚韧膜组织,对于脑组织起着支持和保护作用。由于肿瘤切除、炎症破坏和开颅手术等原因造成硬脑膜缺损的现象在临床上越发常见,因此,开发有效的硬脑膜修复材料以减少脑脊液泄露和降低癫痫等并发症发生,促进其恢复正常生理结构是再生医学的必然要求。目前,最具有潜力且研究最多的生物材料是合成高分子材料和天然高分子材料。合成高分子材料具有性能稳定、低异物感染和易于量产等优势,受到国内外学者的广泛研究;天然高分子材料具有来源广泛、优异的生物相容性和生物可降解性等优势,被认为是最具有希望的生物材料。主要对合成高分子材料和天然高分子材料在硬脑膜修复中的应用进展进行综述。The dura mater is a double-layer tough membrane tissue located between the surface of the brain and the inner surface of the skull that supports and protects the brain tissue.The phenomenon of dural defects caused by tumor resection,inflammation destruction,and craniotomies is becoming more common clinically.Therefore,the development of effective dural repair materials can not only reduce the leakage of cerebrospinal fluid and the occurrence of epilepsy complications but also promote the recovery of the dural defect to its normal physiological structure.With the continuous development of modern medicine,many biomaterials have been developed for dural defect repair.At present,the most promising and most researched biomaterials are synthetic polymer materials and natural polymer materials.Synthetic polymer materials have been extensively studied by domestic and foreign scholars due to their stable performance,low foreign body infection,and easy mass production advantages.Natural polymer materials are the most promising biomaterials because of their extensive sources,excellent biocompatibility,and biodegradability advantages.This article summarizes the research progress based on synthetic polymer materials and natural polymer materials in dural repair materials.In this review paper,the application progress of synthetic polymer materials and natural polymer materials in dural membrane repair was reviewed.

关 键 词：硬脑膜 合成高分子材料 天然高分子材料 

分 类 号：R318.08[医药卫生—生物医学工程]