我国青年学生干眼症患病率的meta分析  

Meta-analysis of prevalence of dry eye syndrome among young students in China

作　　者：武佳敏 刘文莲 刘畅[1] 何敏媚[1] WU Jia-min;LIU Wen-lian;LIU Chang;HE Min-mei(School of Management,Beijing University of Traditional Chinese Medicine,Beijing,100029,China)

机构地区：[1]北京中医药大学管理学院,北京100029

出　　处：《职业与健康》2023年第10期1397-1402,共6页Occupation and Health

摘　　要：目的 采用meta分析方法获取我国青年学生干眼症患病率,为干眼症的预防和控制提供科学依据。方法 检索知网、万方、维普、读秀、CBM、web of science、PubMed、Springer link、Elsevier等国内外数据库关于我国青年学生干眼症的横断面调查,检索时限为建库至2022年3月,并追溯参考文献作为补充。严格设定纳入和排除标准,利用R软件使用随机效用模型计算干眼症合并患病率,并对性别、诊断标准、地区和学段进行亚组分析,探索异质性来源。采用敏感性分析检验结果是否稳健,使用漏斗图、Begg秩相关检验和Egger回归分析检验是否存在发表偏倚。结果 最终纳入22篇文献,纳入的研究总样本量为30 139名,干眼症患者9 453名。Meta分析结果显示,我国青年学生干眼症患病率为29.25%,95%CI为22.69%~37.71%。亚组分析显示,不同地区、诊断标准之间患病率差异均有统计学意义,不同学段、性别学生干眼症患病率比较,差异均无统计学意义(均P>0.05)。结论 我国青年学生干眼症患病率较高,并且高于全球平均患病率。单组率的meta分析结果可靠,需要采取积极的策略加强青年学生干眼症的早期预防。Objective To obtain the prevalence of the dry eye syndrome among young students in China by using meta-analysis method,provide scientific evidence for the prevention and control of dry eye syndrome.Methods The cross-sectional surveys on dry eye syndrome among young students in China were searched on domestic and international databases,such as CNKI,Wanfang,VIP,Readshow,CBM,web of science,PubMed,Springer link and Elsevier,and supplemented by retrospective references.The search time period was from database creation to March 2022.The inclusion and exclusion criteria were strictly defined,and the combined prevalence of dry eye syndrome was calculated using a random utility model with R software,and subgroup analysis was performed to explore sources of heterogeneity by gender,diagnosis criteria,region,and school segment.The sensitivity analysis was used to test the robustness of the results,and funnel plots,Begg's rank correlation test,and Egger regression analysis were used to test for publication bias.Results Totally 22 publications were finally included,with a total sample size of 30139 students and 9453 patients with dry eye syndrome.The meta-analysis showed that the prevalence of dry eye syndrome among young students in China was 29.25%and 95%CI was 22.69%-37.71%.The subgroup analysis showed that there were statistically significant differences in the prevalence between different regions and diagnostic criteria,while the differences were not statistically significant between different grades and genders.Conclusions The prevalence of dry eye syndrome among young students in China is comparatively high,and higher than the worldwide average prevalence.The results of the metaanalysis of single-group rates are reliable,requiring active strategies to enhance the early prevention of dry eye syndrome in young students.

关 键 词：干眼症 患病率 青年学生 

分 类 号：R181.2[医药卫生—流行病学]