番荔枝果皮弱极性成分研究(Ⅲ)  

Weak polar constituents from the pericarps of Annona squamosa(Ⅲ)

作　　者：陈亚运 陈欢 阙丽君 吴心怡 高艳云 CHEN Ya-yun;CHEN Huan;QUE Li-jun;WU Xin-yi;GAO Yan-yun(Taizhou Polytechnic College,Taizhou 225300,China;Jiangsu Engineering Technology Research Center of Solid Preparation,Taizhou 225300,China;Affiliated Hospital to Nanjing University of Chinese Medicine,Nanjing 210004,China)

机构地区：[1]泰州职业技术学院,江苏泰州225300 [2]江苏省固体制剂工程技术研究中心,江苏泰州225300 [3]南京中医药大学附属医院,江苏南京210004

出　　处：《中成药》2023年第6期1883-1886,共4页Chinese Traditional Patent Medicine

基　　金：泰州市科技局项目(2020);泰州市“凤城英才”托举工程项目(2021);江苏省中医院科研项目(2022);江苏省“青蓝工程”资助项目(2022);泰州职业技术学院科研项目(2022)。

摘　　要：目的研究番荔枝Annona squamosa Linn.果皮弱极性成分。方法番荔枝果皮95%乙醇提取物采用硅胶柱进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到6个化合物,分别鉴定为16α-17-acetoxy-18-nor-ent-kaurane-4β-ol(1)、ent-kaurane-16-en-19-ol(2)、ent-kuarane-15-en-17-al-18-oic acid(3)、ent-kuarane-15-en-17-al-19-oic acid(4)、16α,17-dihydroxy-ent-kaurane-19-oic acid methyl ester(5)、16α-ent-kaurane-17-ol(6)。结论化合物1为新化合物,化合物3~6均为首次从番荔枝果皮中分离得到。AIM To study the weak polar constituents from the pericarps of Annona squamosa Linn..METHODS The 95%ethanol extract from the pericarps of A.squamosa was isolated and purified by silica gel column,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Six compounds were isolated and identified as 16α-17-acetoxy-18-nor-ent-kaurane-4β-ol(1),ent-kaurane-16-en-19-ol(2),ent-kuarane-15-en-17-al-18-oic acid(3),ent-kuarane-15-en-17-al-19-oic acid(4),16α,17-dihydroxy-ent-kaurane-19-oic acid methyl ester(5),16α-ent-kaurane-17-ol(6).CONCLUSION Compound 1 is a new compound.Compounds 3-6 are isolated from the pericarps of A.squamosa for the first time.

关 键 词：番荔枝 果皮 分离鉴定 弱极性成分 

分 类 号：R284.1[医药卫生—中药学]