三白草地上部分化学成分研究  

Chemical constituents from aerial parts of Saururus chinensis

作　　者：葛雯 陈建伟[2] 李祥[2] 李金枝 蔡红蝶 陶倩 罗益远 陈宏降 GE Wen;CHEN Jian-wei;LI Xiang;LI Jin-zhi;CAI Hong-die;TAO Qian;LUO Yi-yuan;CHEN Hong-jiang(Zhejiang Pharmaceutical University,Ningbo 315500,China;College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China)

机构地区：[1]浙江药科职业大学,浙江宁波315500 [2]南京中医药大学药学院,江苏南京210046

出　　处：《中草药》2023年第11期3417-3423,共7页Chinese Traditional and Herbal Drugs

基　　金：浙江省公益技术研究计划项目(LTGN23H280004);浙江省药品监管系统科技计划项目(2023014);浙江省教育厅一般项目(Y202249869,Y202250192,Y202250217,Y202249945);宁波市自然科学基金项目(2021J187,202003N4335)。

摘　　要：目的研究三白草Saururuschinensis地上部分的化学成分。方法采用超临界CO_(2)萃取,硅胶、ODS、MCIGel柱色谱和半制备高效液相色谱等色谱技术进行系统的分离纯化,根据光谱数据和理化性质进行化合物的结构鉴定。结果从三白草地上部分的超临界CO_(2)萃取物中分离得到15个化合物,分别鉴定为2,3-二甲基-1,4-二(3,4,5-三甲氧基苯基)-1,4-丁二酮(1)、asperphenamate(2)、rel-(7S,8S,7’R,8’R)-3,3’,4,4’,5,5’-六甲氧基-7-O-7’,8.8’-木脂素(3)、常春藤皂苷元(4)、schisandlignans C(5)、樟叶素(6)、4-羟基-5-甲基己烷-5-内酯(7)、异黑麦草内酯(8)、perseal B(9)、myrisfragransin(10)、heteroplexisolide E(11)、curcasinlignan C(12)、去氢催吐萝芙木醇(13)、黑麦草内酯(14)和三白草二萜E(15)。结论化合物15为新化合物,化合物1为新的天然产物;除化合物3、6、13外均为首次从该植物中分离得到。Objective To study the chemical constituents from aerial part of Sanbaicao[Saururus chinensis(Lour.)Baill.].Methods In this study,after supercritical CO_(2)extracting,the chemical constituents were isolated by various chromatographic methods,such as silica gel,ODS,MCI and semi-preparation HPLC,and their structures were identified by spectral data and physicochemical property.Results Fifteen compounds were isolated and identified as 2,3-dimethyl-1,4-bis(3,4,5-trimethoxyphenyl)butane-1,4-dione(1),asperphenamate(2),rel-(7S,8S,7'R,8'R)-3,3',4,4',5,5'-hexamethoxy-7-O-7',8.8'-lignan(3),hederagenin(4),schisandlignans C(5),polysyphorin(6),4-hydroxy-5-methylhexan-5-olide(7),isololiolide(8),perseal B(9),myrisfragransin(10),heteroplexisolide E(11),curcasinlignan C(12),dehydrovomifoliol(13),loliolide(14)and sauruditerpene E(15).Conclusion Compound 15 is a new compound,compound 1 is a new natural compound,and the others are isolated from this plant for the first time except compounds 3,6 and 13.

关 键 词：三白草 三白草二萜E (2S 3R)-2 3-二甲基-1 4-二(3 4 5-三甲氧基苯基)-1 4-丁二酮 常春藤皂苷元 异黑麦草内酯 

分 类 号：R284.1[医药卫生—中药学]