经典名方开心散治疗阿尔茨海默病的机制研究进展  

Research progress on mechanism of classic famous prescription Kaixin Powder in treatment of Alzheimer’s disease

作　　者：单晓晓 周乐乐 李大伟 尹慧慧 陶稳稳 李俊莹 杨璇 彭灿 金传山 汪小莉 张彩云 SHAN Xiao-xiao;ZHOU Le-le;LI Da-wei;YIN Hui-hui;TAO Wen-wen;LI Jun-ying;YANG Xuan;PENG Can;JIN Chuan-shan;WANG Xaio-li;ZHANG Cai-yun(School of Pharmacy,Anhui University of Traditional Chinese Medicine,Hefei 230012,China;Institute of Pharmaceutics,Anhui Academy of Chinese Medicine,Hefei 230012,China;Engineering Technology Research Center of Modernized Pharmaceutics,Anhui Education Department(AUCM),Hefei 230012,China;Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center,Hefei 230012,China;Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application,Hefei 230012,China;Anhui Key Laboratory of Compound Chinese Materia Medica,Hefei 230012,China)

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]药物制剂技术与应用安徽省重点实验室,安徽合肥230012 [3]安徽省教育厅现代药物制剂工程技术研究中心,安徽合肥230012 [4]安徽省道地中药材品质提升创新协同中心,安徽合肥230012 [5]安徽省中医药科学院药物制剂研究所,安徽合肥230012 [6]中药复方安徽省重点实验室,安徽合肥230012

出　　处：《中草药》2023年第11期3685-3695,共11页Chinese Traditional and Herbal Drugs

基　　金：安徽省科技重大专项项目(202203a07020031);安徽省教育厅基金项目(KJ2021ZD0065);国家级大学生创新创业训练计划项目(202210369022)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍和记忆损害为特征的神经退行性疾病,临床主要表现为记忆力减退、语言障碍、情感和行为异常等。开心散源于《备急千金要方》,已有研究证实开心散中的远志皂苷、人参皂苷、茯苓三萜类和多糖类化合物、α-细辛醚及β-细辛醚等成分,可通过调节丝裂原活化蛋白激酶/核因子-κB、磷脂酰肌磷脂酰肌醇3-激酶/蛋白激酶B/糖原合成酶激酶-3β和Kelch样ECH关联蛋白1/核因子E2相关因子2/锰超氧化物歧化酶等炎症相关信号通路及抗氧化应激、抑制tau蛋白过度磷酸化、抑制神经细胞凋亡和调节胆碱能系统等机制治疗AD,在临床防治AD方面前景广阔。通过对开心散治疗AD的药效基础及治疗AD相关作用机制进行综述,为开心散的新药研发和临床应用奠定基础。Alzheimer’s disease(AD)is a neurodegenerative disease characterized by progressive cognitive dysfunction and memory impairment.The main clinical manifestations are memory loss,language impairment,emotional and behavioral abnormalities.Kaixin Powder(开心散,KXP)is derived from Valuable Prescriptions for Emergency.Studies have confirmed that KSP contains polygala saponins,ginsenosides,poria triterpenoids and polysaccharides,α-andβ-asarone,etc.,can regulate inflammation-related signaling pathways such as mitogen-activated protein kinases/nuclear factor-κB,phosphatidylinositol 3-kinase/protein kinase B/glycogen synthasekinase-3βand Kelch-like ECH-associated protein 1/nuclear factor E2 related factor 2/manganese superoxide dismutase,as well as anti-oxidative stress,inhibit tau protein hyperphosphorylation,inhibit neuronal apoptosis,and modulate the cholinergic system.KSP has great potential in the clinical prevention and treatment of AD.This article reviews the pathogenesis of AD,the pharmacodynamic material basis of KSP in the treatment of AD and the related mechanism,laying the foundation for the new drug research and clinical application of the classic famous prescription KSP.

关 键 词：开心散 阿尔茨海默病 药效物质基础 丝裂原活化蛋白激酶/核因子-κB 炎症 氧化应激 远志皂苷 人参皂苷 茯苓三萜 Α-细辛醚 

分 类 号：R285[医药卫生—中药学]