迷迭香酸药理作用及其递送系统的研究进展  

Research progress on pharmacological effect and delivery system of rosmarinic acid

作　　者：龙苗苗 程贤[1] 赵振东[1] 陈玉湘[1] 毕良武[1] LONG Miao-miao;CHENG Xian;ZHAO Zhen-dong;CHEN Yu-xiang;BI Liang-wu(Institute of Chemical Industry of Forest Products CAF,Nanjing 210042,China;Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,Nanjing Forestry University,Nanjing 210037,China;Department of Pharmacy,Wuxi Higher Health Vocational Technology School,Wuxi 214028,China)

机构地区：[1]中国林业科学研究院林产化学工业研究所,江苏南京210042 [2]南京林业大学江苏省林业资源高效加工利用协同创新中心,江苏南京210037 [3]无锡卫生高等职业技术学校药学系,江苏无锡214028

出　　处：《中草药》2023年第11期3715-3724,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(32201512);广西科技重大专项(AA20302021-7);浙江省林业科技项目(2022SY07)。

摘　　要：迷迭香酸是从迷迭香等植物中分离得到的一种多酚类化合物,具有显著的抗氧化、抗炎、抗微生物、抗肿瘤及神经保护等作用。然而,由于溶解度差、渗透性低、光不稳定性、体内靶向性差、代谢速率快等缺点,限制了其药理活性及临床产品开发。药物递送系统能够在改善药物的理化性质、保护药物稳定性、发挥更佳给药途径和提高生物利用度等方面具有显著优点。通过对迷迭香酸的药理作用及新型药物载体用于迷迭香酸递送的研究进展进行综述,为迷迭香酸的药物开发和临床应用提供参考。Rosmarinic acid is a polyphenolic compound isolated from midiexiang(Rosmarinus officinalis)and other plants with significant anti-oxidant,anti-inflammatory,antibacterial,antitumor,and neuroprotective effects.However,rosmarinic acid has some disadvantages such as low solubility and permeability,photoinstability,in vivo poor targeting and fast metabolic rate,which limit its pharmacological activities and clinical drugs development.Drug delivery systems offer significant advantages in terms of improving the physicochemical properties,protecting stability,achieving better administration routes and increasing bioavailability.In this paper,the different pharmacological effects activities of rosmarinic acid were introduced,and the research progress of new carriers for the delivery of rosmarinic acid delivery systems were reviewed,which provide reference for the development and clinical application of rosmarinic acid.

关 键 词：迷迭香酸 药物递送系统 抗氧化 纳米载体 生物利用度 

分 类 号：R285[医药卫生—中药学]