五味子中1个新的联苯环辛烯类木脂素  

A new dibenzocyclooctadiene lignan from Schisandra chinensis

作　　者：邸同莲 刘小清 吴楠 陈孝源 范君婷[3] 谭宁华[1] DI Tong-lian;LIU Xiao-qing;WU Nan;CHEN Xiao-yuan;FAN Jun-ting;TAN Ning-hua(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Beijing Haiyan Pharmaceutical Co.,Ltd.,Yangtze River Pharmaceutical Group,Beijing 102206,China;School of Pharmacy,Nanjing Medical University,Nanjing 211116,China)

机构地区：[1]中国药科大学中药学院,江苏南京211198 [2]扬子江药业集团北京海燕药业有限公司,北京102206 [3]南京医科大学药学院,江苏南京211116

出　　处：《中草药》2023年第12期3759-3770,共12页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(32070356)。

摘　　要：目的研究中药五味子Schisandra chinensis的木脂素类化学成分。方法采用硅胶柱色谱、中压反相柱色谱、半制备和制备液相对五味子中富含木脂素类成分的石油醚萃取部位进行分离、纯化,通过波谱数据鉴定化合物的结构。结果从五味子中分离得到了26个化合物,分别鉴定为绿叶五味子素B(1)、sphaerandrin A(2)、sieverlignan E(3)、arisanschinin G(4)、widdaranalF(5)、戈米辛A(6)、戈米辛B(7)、戈米辛D(8)、戈米辛G(9)、(-)-戈米辛K_(1)(10)、(+)-戈米辛K_(2)(11)、(-)-戈米辛L_(1)(12)、(+)-戈米辛M_(1)(13)、戈米辛N(14)、当归酰戈米辛H(15)、当归酰戈米辛O(16)、当归酰戈米辛Q(17)、苯甲酰戈米辛Q(18)、五味子醇甲(19)、五味子甲素(20)、五味子乙素(21)、五味子丙素(22)、五味子酯丙(23)、neglschisandrin E(24)、7(18)-dehydroschisandro A(25)、安五脂素(26),其中24个为联苯环辛烯类木脂素(1~4、6~25)。结论化合物1为新化合物,化合物2~5为首次从该植物中分离得到。Objective To study the lignans in Schisandra chinensis.Methods The petroleum ether extract mainly contained lignans of S.chinensis was isolated and purified by silica gel column chromatography,medium pressure reversed phase column chromatography,semi-prepared and prepared liquid chromatography.The structures of compounds were identified by spectral data.Results Twenty-six compounds were obtained,in which 24 were dibenzocyclooctadiene lignans.They were identified as schiviridin B(1),sphaerandrin A(2),sieverlignan E(3),arisanschinin G(4),widdaranal F(5),gomisin A(6),gomisin B(7),gomisin D(8),gomisin G(9),(−)-gomisin K_(1)(10),(+)-gomisin K_(2)(11),(−)-gomisin L_(1)(12),(+)-gomisin M_(1)(13),gomisin N(14),angeloylgomisin H(15),angeloylgomisin O(16),angeloylgomisin Q(17),benzoylgomisin Q(18),schisandrin(19),schisandrin A(20),γ-schisandrin(21),schisandrin C(22),schisantherin C(23),neglschisandrin E(24),7(18)-dehydroschisandro A(25),and anwulignan(26).Conclusion Compound 1 is new and compounds 2—5 are isolated from this plant for the first time.

关 键 词：五味子 绿叶五味子素B 联苯环辛烯类木脂素 sphaerandrin A sieverlignan E arisanschinin G widdaranal F 五味子醇甲 

分 类 号：R284.1[医药卫生—中药学]