黄芪多糖提取工艺、化学结构及药理作用的研究进展  

Research progress on extraction technology,chemical structure and pharmacological action of Astragalus polysaccharides

作　　者：杨乾方 王帆[2] 叶婷[3] 潘立民 YANG Qian-fang;WANG Fan;YE Ting;PAN Li-min(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Harbin Medical University,Harbin 150081,China;The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]哈尔滨医科大学,黑龙江哈尔滨150081 [3]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150000 [4]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150000

出　　处：《中草药》2023年第12期4069-4081,共13页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省科学基金资助项目(QC2017115);黑龙江省中医药科研资助项目(ZHY2020-152);黑龙江省博士后科研启动金资助项目(LBH-Q19180)。

摘　　要：黄芪多糖(Astragalus polysaccharides,APS)是黄芪的重要活性成分之一,随着黄芪在临床上的使用越来越广泛,学者对APS的提取工艺、化学结构及药理作用的研究也愈来愈深入。不同的提取工艺对APS的含量和纯度均会产生不同程度的影响,进而对其药理作用的发挥也会有所影响。APS具有调节免疫、抗肿瘤、降血糖、抗衰老和抗炎等药理作用。在全面查阅并梳理文献资料的基础上,对APS的提取工艺、化学结构及药理作用进行综述,并对APS的研究前景进行展望,以期对APS的进一步开发利用和研究提供有效的理论支持。Astragalus polysaccharides(APS)is one of the most important active components of Astragali Radix.With the increasing use of Astragali Radix in clinical practice,scholars have conducted more and more in-depth research on the extraction process,chemical structure and pharmacological effects of APS.Different extraction processes have different effects on the content and purity of APS,as well as their pharmacological effects.APS has pharmacological effects such as immunomodulatory,anti-tumor,hypoglycemic,anti-aging and anti-inflammatory.In this paper,the extraction process,chemical structure and pharmacological action of APS were reviewed on the basis of comprehensive review and review of literature,and the research prospect of APS was prospected,in order to provide effective theoretical support for the further development and utilization of APS.

关 键 词：黄芪多糖 提取工艺 化学结构 免疫调节 抗肿瘤 

分 类 号：R28[医药卫生—中药学]