乙型肝炎病毒cccDNA动力学的思维框架  

A conceptual framework for dynamics of cccDNA in hepatitis B virus

作　　者：胡接力[1] 黄爱龙[1] Hu Jieli;Huang Ailong(Key Laboratory of Molecular Biology for Infectious Diseases,Ministry of Education,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学感染性疾病分子生物学教育部重点实验室,重庆400016

出　　处：《中华肝脏病杂志》2023年第5期545-550,共6页Chinese Journal of Hepatology

基　　金：国家重点研发计划(2022YFA1303600)。

摘　　要：丙型肝炎问题的解决,增强了人们对治愈慢性乙型肝炎的希望,并促使业界投入更多研发力量,发展乙型肝炎功能性治愈策略。这些策略种类繁多,发表的研究结果庞杂。对这些策略进行理论分析,对确定优先研究方向,合理配置研发资源有重要意义。然而,由于缺少必要的思维模型,目前的理论分析,未能将各种治愈策略统一到一个合适的理论框架中去。鉴于cccDNA的数量减少,是功能性治愈过程中必然伴随的核心事件,现提出以cccDNA动力学为框架,分析各种慢性乙型肝炎治愈策略。目前,领域内对cccDNA动力学的探讨很少,希望借此文能促进对cccDNA动力学的认识和研究。The resolution of the hepatitis C issue has raised expectations for a chronic hepatitis B cure,driving the industry to expand investment in research and development efforts to strengthen functional cure strategies.These strategies have a wide variety of types,and the published research findings are heterogeneous.The theoretical analysis of these strategies is of great significance for determining prioritized research orientations as well as sensibly allocating research and development resources.However,due to a paucity of necessary conceptual models,current theoretical analysis has not been able to unify various therapeutic strategies into a proper theoretical framework.In view of the fact that the decrease in the quantity of cccDNA is an inevitable core event accompanied by the process of functional cure,this paper intends to analyze several chronic hepatitis B cure strategies using cccDNA dynamics as a framework.Furthermore,there are currently few studies on the dynamics of the cccDNA field,hoping that this article can promote recognition and research in this field.

关 键 词：慢性乙型肝炎 乙型肝炎病毒 共价闭合环状DNA 

分 类 号：R512.62[医药卫生—内科学]