3D生物打印在骨组织血管网络形成中的研究进展  

Research progress of three dimensional bio-printing technology for formation of vascular network in bone tissue

作　　者：翟传兴 王志梦 王国栋[2] 张元民[2] ZHAI Chuanxing;WANG Zhimeng;WANG Guodong;ZHANG Yuanmin(Clinical Medical College of Jining Medical College,Jining 272067,China;Department of Joint and Sports Medicine,Affiliated Hospital of Jining Medical College,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,山东省济宁市272067 [2]济宁医学院附属医院关节与运动医学科,山东省济宁市272067

出　　处：《组织工程与重建外科》2023年第3期298-301,共4页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：国家自然科学基金(81871814);济宁市重点研发计划(2018SMNS002)。

摘　　要：骨移植物的血管化是骨组织工程(Bone tissue engineering,BTE)面临的主要挑战之一。血管化BTE构建的最终目标是提供一个富含功能性血管网络的骨环境,实现高效的骨整合,加速植入后的功能恢复。本文对3D生物打印在骨组织血管网络形成中的研究进展进行综述,详细阐述了血管网络形成机制及3D生物打印技术的特点,重点总结目前BTE中的血管化策略,并对其发展前景进行展望。Vascularization of bone grafts is one of the major challenges facing bone tissue engineering(BTE).The ultimate goal of the construction of vascularized BTE is to provide a bone environment rich in functional vascular networks to achieve efficient bone integration and accelerate the functional recovery after implantation.In this paper,the research progress of 3D bio-printing in the formation of vascular network in bone tissue was reviewed,the formation mechanism of vascular network and the characteristics of 3D bio-printing technology were elaborated,the current vascularization strategies in BTE were summarized,and its development prospects were prospected.

关 键 词：3D 生物打印 骨组织工程 血管网络 血管化 

分 类 号：R318.1[医药卫生—生物医学工程]