组织工程化韧带及其材料的研究进展  

Research progress of tissue engineering ligament and scaffold materials

作　　者：钟睿 高竞宇 严承远 陆帅 刘芷麟 方超 余刚 王英明 赵其纯 ZHONG Rui;GAO Jingyu;YAN Chengyuan;LU Shuai;LIU Zhilin;FANG Chao;YU Gang;WANG Yingming;ZHAO Qichun(Department of Sports Medicine,The First Affiliated Hospital of USTC,Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院运动医学科,安徽省合肥市230001

出　　处：《组织工程与重建外科》2023年第3期308-314,共7页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：安徽省重点研究和开发计划项目(201904a07020088);2020年度“科大新医学”联合基金(WK9110000143)。

摘　　要：现有人工韧带产品的重建方案在临床应用中已相对成熟,为防止韧带重建术后的腱-骨愈合困难、骨隧道扩大、滑膜炎性反应、感染、外固定松动等术后并发症的出现,利用组织工程技术构建肌腱组织成为今后可能的发展方向。本文综述组织工程化肌腱的构建及其支架材料的进展,探讨其中亟待解决的问题与未来的发展方向。The reconstruction scheme of the existing artificial ligament products has been relatively mature in clinical application.In order to prevent the occurrence of postoperative complications such as difficult tendon-bone healing,expansion of the bone tunnel,synovial inflammatory reaction,infection,and external fixation loosening after ligament reconstruction,tendon tissue construction using tissue engineering technology has become a possible development direction in the future.In this paper,the progress of the construction of tissue-engineered tendon and its scaffold materials was reviewed,the urgent problems to be solved and the future development direction were discussed.

关 键 词：前交叉韧带 腱-骨愈合 人工韧带 组织工程 生物支架 

分 类 号：R318.1[医药卫生—生物医学工程] R318.08[医药卫生—基础医学]