十二烷基氯化吡啶合成工艺的热危险性研究  

Study on the Thermal Hazard of the Synthesis Process of Dodecyl Pyridine Chloride

作　　者：王晓飞 林树东[1,2,3] 桂雪峰 赵吉合 胡继文 WANG Xiao-fei;LIN Shu-dong;GUI Xue-feng;ZHAO Ji-he;HU Ji-wen(Guangzhou Institute of Chemistry,Chinese Academy of Sciences,CAS Engineering Laboratory for Special Fine Chemicals,Guangdong Provincial Key Laboratory of Organic Polymer Materials for Electronics,Guangzhou 510650,China;CASH GCC Shaoguan Research Institute of Advanced Materials,Incubator of Nanxiong CAS Co.,Ltd.,Nanxiong 512400,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院广州化学研究所中国科学院新型特种精细化学品工程实验室广东省电子有机聚合物材料重点实验室,广东广州510650 [2]国科广化韶关新材料研究院国科广化精细化工孵化器(南雄)有限公司,广东南雄512400 [3]中国科学院大学,北京100049

出　　处：《广州化学》2023年第3期45-48,共4页Guangzhou Chemistry

基　　金：国家自然科学基金(21404121);广州市科技计划重点项目(201904020019)。

摘　　要：利用全自动反应量热仪(RC1mx)、差示扫描量热仪(DSC)和绝热加速量热仪(ARC)检测十二烷基氯化吡啶合成反应的反应热、最大反应温度及热稳定性,依据绝热温升(ΔT_(ad))、最大反应速率到达时间为24 h的温度(T_(D24))和失控体系可能达到的最高温度(MTSR)等温度参数对工艺危险性进行评估。结果显示,ΔT_(ad)为276.2 K,T_(D24)为290℃,MTSR为165.6℃。经过研究反应温度和吡啶滴加时间,确认了145℃是合理的反应温度。如果缩短吡啶滴加时间会导致物料累积,影响反应转化率,增加危险性。The reaction heat,specific heat capacity,and thermal stability of the synthesis reaction of dodecylpyridinium chloride were measured using a fully automated reaction calorimeter(RC1mx),differential scanning calorimeter(DSC),and accelerating rate calorimeter(ARC).The process risk is evaluated based on temperature parameters such as adiabatic temperature rise(ΔT_(ad)),a temperature with a maximum reaction rate arrival time of 24 hours(T_(D24)),and the maximum temperature that may be reached by the runaway system(MTSR).The results showed that the ΔT_(ad) was 276.2 K,T_(D24) was 290℃,and MTSR was 165.6℃.After examining the reaction temperature and pyridine titration time,it was determined that 145℃was an acceptable reaction temperature.After studying the reaction temperature and pyridine dropping time,it is confirmed that 145℃is a reasonable reaction temperature.If the dropping time of pyridine was shortened,the reaction material would accumulate,which would affect the reaction conversion rate and increase the risk.

关 键 词：十二烷基氯化吡啶 反应量热仪 差示扫描量热仪 绝热加速量热仪 热风险评估 

分 类 号：O621.3[理学—有机化学]