3D生物打印中复合水凝胶生物墨水的研究进展  

Research progress of composite hydrogel bioink in 3D bioprinting

作　　者：孙兆丰 王国栋 翟传兴[1,2] 张元民 SUN Zhaofeng;WANG Guodong;ZHAI Chuanxing;ZHANG Yuanmin(Clinical Medical College of Jining Medical College,Jining,Shandong 272067,China;Department of Bone andJoint Surgery,Affiliated Hospital of Jining Medical College,Jining,Shandong 272067,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]济宁医学院附属医院骨关节外科,山东济宁272067

出　　处：《中国医学工程》2023年第6期50-54,共5页China Medical Engineering

基　　金：国家自然科学基金项目(81871814)。

摘　　要：近年来,3D生物打印作为一种新兴生物增材制造技术,被广泛应用于体外功能组织和类器官结构开发。一种可负载细胞的水凝胶生物墨水,不仅能为组织发育提供稳定的3D架构,还可充当细胞的第一接触点,从而影响到构建物中细胞数量、增殖、迁移等。然而传统水凝胶生物墨水存在可打印性差、力学性能差、不利于细胞生长的微环境等诸多缺点。近年来,大家致力于复合水凝胶生物墨水的开发,以弥补水凝胶生物墨水的短板,本文正是对增强水凝胶生物墨水性能的策略进行分类归纳,将各种增强策略的方法、优缺点及前景综述,并对水凝胶生物墨水的研发进行了展望。In recent years,3D bioprinting,as a new biological additive manufacturing technology,has been widely used in the development of functional tissues and organoid structures in vitro.A cell-loaded hydrogel bioink can not only provide a stable 3D architecture for tissue development,but also act as the first contact point of cells,thus affecting the number,proliferation and migration of cells in the construct.However,traditional hydrogel bioinks have many disadvantages,such as poor printability,poor mechanical properties and unfavorable microenvironment for cell growth.In recent years,we have been devoted to the development of composite hydrogel bioink to make up for the shortcomings of hydrogel bioink.This paper classifies and summarizes the strategies to enhance the performance of hydrogel bioink,summarizes the methods,advantages,disadvantages and prospects of various enhancement strategies,and looks forward to the research and development of hydrogel bioink.

关 键 词：3D生物打印 生物墨水 水凝胶 

分 类 号：R318.08[医药卫生—生物医学工程]