血小板聚集功能与脓毒症患者脓毒症相关性脑病的关系  

Relationship Between Platelet Aggregation Function and Sepsis Related Encephalopathy in Patients with Sepsis

作　　者：温文乐 周华锋 WEN Wenle;ZHOU Huafeng(Department of Intensive Care Medicine,Zhengzhou Yihe Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州颐和医院重症医学科,河南郑州450000

出　　处：《河南医学研究》2023年第12期2173-2176,共4页Henan Medical Research

摘　　要：目的探究血小板聚集功能与脓毒症患者发生脓毒症相关性脑病的关系。方法采用回顾性分析,收集郑州颐和医院2020年1月至2022年11月收治的126例脓毒症患者临床资料,依据脓毒症相关性脑病发生情况分为发生组(n=66)与未发生组(n=60)。研究者设计一般资料调查表,收集患者一般资料及入院时血小板聚集功能指标[凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、血小板凝血酶原时间(PT)、D-二聚体、血小板最大聚集率],并进行对比;采用点二列相关性分析血小板聚集功能与脓毒症患者发生脓毒症相关性脑病的关系,绘制受试者工作特征(ROC)曲线,评估APTT、PT、血小板最大聚集率单独及联合预测脓毒症患者发生脓毒症相关性脑病的价值。结果两组TT、D-二聚体水平对比,差异无统计学意义(P>0.05);发生组APTT、PT长于未发生组,血小板最大聚集率小于未发生组,差异有统计学意义(P<0.05);点二列相关性分析显示,APTT、PT与脓毒症患者脓毒症相关性脑病的发生呈正相关(r>0,P<0.05),血小板最大聚集率与脓毒症患者脓毒症相关性脑病发生呈负相关(r<0,P<0.05);绘制ROC曲线,结果显示,APTT、PT、血小板最大聚集率预测脓毒症患者脓毒症相关性脑病发生的曲线下面积(AUC)均>0.7,具有一定的预测价值,且联合预测价值更高。结论血小板聚集功能与脓毒症患者发生脓毒症相关性脑病存在相关性,且联合应用APTT、PT及血小板最大聚集率能够较好预测脓毒症患者发生脓毒症相关性脑病。Objective To explore the relationship between platelet aggregation function and sepsis related encephalopathy in patients with sepsis.Methods A retrospective analysis was conducted to collect the clinical data of 126 patients with sepsis admitted to Zhengzhou Yihe Hospital from January 2020 to November 2022.According to the incidence of sepsis related encephalopathy,they were divided into the occurrence group(n=66)and the non-occurrence group(n=60).General data questionnaire was designed by researcher to collect and compare general data of patients and platelet aggregation function indicators[thrombin time(TT),activated partial thromboplastin time(APTT),platelet prothrombin time(PT),D-dimer,and maximum platelet aggregation rate]at admission.The relationship between platelet aggregation function and the occurrence of sepsis related encephalopathy in patients with sepsis was analyzed using a point binary correlation method.The Receiver operating characteristic(ROC)curve was drawn to evaluate the value of APTT,PT and platelet maximum aggregation rate alone and in combination in predicting the occurrence of sepsis related encephalopathy in patients with sepsis.Results There was no statistically significant difference in the levels of TT and D-dimer between the two groups(P>0.05).APTT and PT in the occurrence group were longer than those in the non-occurrence group,and the maximum platelet aggregation rate was lower than that in the non-occurrence group,with a statistically significant difference(P<0.05).Point two column correlation analysis showed that APTT and PT were positively correlated with the occurrence of sepsis related encephalopathy in patients with sepsis(r>0,P<0.05),while the maximum platelet aggregation rate was negatively correlated with the occurrence of sepsis related encephalopathy in patients with sepsis(r<0,P<0.05).The ROC curve was plotted,and the results showed that the area under the curve(AUC)of APTT,PT and maximum platelet aggregation rate predicting the occurrence of sepsis related encephalop

关 键 词：脓毒症 脓毒症相关性脑病 凝血酶原时间 血小板最大聚集率 

分 类 号：R631[医药卫生—外科学]