The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury  

作　　者：Caiyun Liu Haixin Yu Zhengchao Li Shulian Chen Xiaoyin Li Xuyi Chen Bo Chen 

机构地区：[1]School of Acupuncture&Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin,China [2]Research Center of Experimental Acupucture Science,Tianjin University of Traditional Chinese Medicine,Tianjin,China [3]Characteristic Medical Center of Chinese People’s Armed Police Force,Tianjin,China [4]Binhai New Area Hospital of TCM,Tianjin,China [5]Fourth Teaching Hospital of Tianjin University of TCM,Tianjin,China

出　　处：《Neural Regeneration Research》2024年第1期22-28,共7页中国神经再生研究（英文版）

基　　金：supported by the Key Projects of the National Natural Science Foundation of China,No.11932013(to XC);Key Military Logistics Research Projects,No.B WJ21J002(to XC);the Key projects of the Special Zone for National Defence Innovation,No.21-163-12-ZT006002-13(to XC);the National Nature Science Foundation of China No.82272255(to XC);the National Defense Science and Technology Outstanding Youth Science Fund Program,No.2021-JCIQ-ZQ-035(to XC);the Scientific Research Innovation Team Project of Armed Police Characteristic Medical Center,No.KYCXTD0104(to ZL);the National Natural Science Foundation of China Youth Fund,No.82004467(to BC)。

摘　　要：Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.

关 键 词：artificial hibernation central thermostatic-resista nt regulation hypothermia multi-system protection neuroprotection organ protection spinal cord injury synthetic torpor 

分 类 号：R651.2[医药卫生—外科学]